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Am J Physiol Cell Physiol 278: C473-C479, 2000;
0363-6143/00 $5.00
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Vol. 278, Issue 3, C473-C479, March 2000

Stretch-induced activation of Ca2+-activated K+ channels in mouse skeletal muscle fibers

Nora Mallouk and Bruno Allard

Laboratoire de Physiologie des Eléments Excitables, Unité Mixte de Recherche, Centre National de la Recherche Scientifique 5578, Université C. Bernard Lyon I, 69622 Villeurbanne Cedex, France

High-conductance Ca2+-activated K+ (KCa) channels were studied in mouse skeletal muscle fibers using the patch-clamp technique. In inside-out patches, application of negative pressure to the patch induced a dose-dependent and reversible activation of KCa channels. Stretch-induced increase in channel activity was found to be of the same magnitude in the presence and in the absence of Ca2+ in the pipette. The dose-response relationships between KCa channel activity and intracellular Ca2+ and between KCa channel activity and membrane potential revealed that voltage and Ca2+ sensitivity were not altered by membrane stretch. In cell-attached patches, in the presence of high external Ca2+ concentration, stretch-induced activation was also observed. We conclude that membrane stretch is a potential mode of regulation of skeletal muscle KCa channel activity and could be involved in the regulation of muscle excitability during contraction-relaxation cycles.

mechanosensitivity; patch clamp; contraction


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