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Am J Physiol Cell Physiol 277: C1122-C1129, 1999;
0363-6143/99 $5.00
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Vol. 277, Issue 6, C1122-C1129, December 1999

EDITORIAL FOCUS
Calcium transients in single fibers of low-frequency stimulated fast-twitch muscle of rat

Stefanie Carroll, Pierluigi Nicotera, and Dirk Pette

Faculty of Biology, University of Konstanz, D-78457 Constance, Germany

Ca2+ transients were investigated in single fibers isolated from rat extensor digitorum longus muscles exposed to chronic low-frequency stimulation for different time periods up to 10 days. Approximately 2.5-fold increases in resting Ca2+ concentration ([Ca2+]) were observed 2 h after stimulation onset and persisted throughout the stimulation period. The elevated [Ca2+] levels were in the range characteristic of slow-twitch fibers from soleus muscle. In addition, we noticed a transitory elevation of the integral [Ca2+] per pulse with a maximum (~5-fold) after 1 day. Steep decreases in rate constant of [Ca2+] decay could be explained by an immediate impairment of Ca2+ uptake and, with longer stimulation periods, by an additional loss of cytosolic Ca2+ binding capacity resulting from a decay in parvalbumin content. A partial recovery of the rate constant of [Ca2+] decay in 10-day stimulated muscle could be explained by an increasing mitochondrial contribution to Ca2+ sequestration.

calcium buffering; free calcium; mitochondria; parvalbumin; sarcoplasmic reticulum calcium-adenosinetriphosphatase


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