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B inhibitor curcumin
stimulates muscle regeneration after traumatic injury
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322
Skeletal muscle is
often the site of tissue injury due to trauma, disease, developmental
defects or surgery. Yet, to date, no effective treatment is available
to stimulate the repair of skeletal muscle. We show that the kinetics
and extent of muscle regeneration in vivo after trauma are greatly
enhanced following systemic administration of curcumin, a
pharmacological inhibitor of the transcription factor NF-
B.
Biochemical and histological analyses indicate an effect of curcumin
after only 4 days of daily intraperitoneal injection compared with
controls that require >2 wk to restore normal tissue architecture.
Curcumin can act directly on cultured muscle precursor cells to
stimulate both cell proliferation and differentiation under appropriate
conditions. Other pharmacological and genetic inhibitors of NF-B
also stimulate muscle differentiation in vitro. Inhibition of
NF-B-mediated transcription was confirmed using reporter gene
assays. We conclude that NF-B exerts a role in regulating myogenesis
and that modulation of NF-B activity within muscle tissue is
beneficial for muscle repair. The striking effects of curcumin on
myogenesis suggest therapeutic applications for treating muscle injuries.
transcription factor; muscle differentiation; dominant-negative; pyrrolidine dithiocarbamate; retrovirus
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