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Am J Physiol Cell Physiol 276: C395-C403, 1999;
0363-6143/99 $5.00
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Vol. 276, Issue 2, C395-C403, February 1999

Prolonged contraction-relaxation cycle of fast-twitch muscles in parvalbumin knockout mice

B. Schwaller1, J. Dick2, G. Dhoot3, S. Carroll4, G. Vrbova2, P. Nicotera4, D. Pette4, A. Wyss5, H. Bluethmann5, W. Hunziker5, and M. R. Celio1

1 Institute of Histology and General Embryology and "Program in Neuroscience," University of Fribourg, CH-1705 Fribourg, Switzerland; 2 Department of Anatomy, University College, London WC1E 6BT; 3 Royal Veterinary College, London NW1 0TU, United Kingdom; 4 Institute of Toxicology, Faculty of Biology, University of Constance, D-78457 Constance, Germany; and 5 Roche Vitamins Division, Hoffmann-LaRoche, 4070 Basel, Switzerland

The calcium-binding protein parvalbumin (PV) occurs at high concentrations in fast-contracting vertebrate muscle fibers. Its putative role in facilitating the rapid relaxation of mammalian fast-twitch muscle fibers by acting as a temporary buffer for Ca2+ is still controversial. We generated knockout mice for PV (PV -/-) and compared the Ca2+ transients and the dynamics of contraction of their muscles with those from heterozygous (PV +/-) and wild-type (WT) mice. In the muscles of PV-deficient mice, the decay of intracellular Ca2+ concentration ([Ca2+]i) after 20-ms stimulation was slower compared with WT mice and led to a prolongation of the time required to attain peak twitch tension and to an extension of the half-relaxation time. The integral [Ca2+]i in muscle fibers of PV -/- mice was higher and consequently the force generated during a single twitch was ~40% greater than in PV +/- and WT animals. Acceleration of the contraction-relaxation cycle of fast-twitch muscle fibers by PV may confer an advantage in the performance of rapid, phasic movements.

EF hand; calcium-binding protein; muscle relaxation; homologous recombination


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