Am J Physiol Cell Physiol Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Cell Physiol 276: C82-C90, 1999;
0363-6143/99 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Johanson, C. E.
Right arrow Articles by McMillan, P. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Johanson, C. E.
Right arrow Articles by McMillan, P. N.
Vol. 276, Issue 1, C82-C90, January 1999

AVP V1 receptor-mediated decrease in Clminus efflux and increase in dark cell number in choroid plexus epithelium

Conrad E. Johanson1, Jane E. Preston1, Adam Chodobski1, Edward G. Stopa2, Joanna Szmydynger-Chodobska1, and Paul N. McMillan2

1 Program in Neurosurgery, Department of Clinical Neurosciences and 2 Department of Pathology, Brown University/Rhode Island Hospital, Providence, Rhode Island 02903

The cerebrospinal fluid (CSF)-generating choroid plexus (CP) has many V1 binding sites for arginine vasopressin (AVP). AVP decreases CSF formation rate and choroidal blood flow, but little is known about how AVP alters ion transport across the blood-CSF barrier. Adult rat lateral ventricle CP was loaded with 36Cl-, exposed to AVP for 20 min, and then placed in isotope-free artificial CSF to measure release of 36Cl-. Effect of AVP at 10-12 to 10-7 M on the Cl- efflux rate coefficient (in s-1) was quantified. Maximal inhibition (by 20%) of Cl- extrusion at 10-9 M AVP was prevented by the V1 receptor antagonist [beta -mercapto-beta ,beta -cyclopentamethyleneproprionyl1,O-Me-Tyr2,Arg8]vasopressin. AVP also increased by more than twofold the number of dark and possibly dehydrated but otherwise morphologically normal choroid epithelial cells in adult CP. The V1 receptor antagonist prevented this AVP-induced increment in dark cell frequency. In infant rats (1 wk) with incomplete CSF secretory ability, 10-9 M AVP altered neither Cl- efflux nor dark cell frequency. The ability of AVP to elicit functional and structural changes in adult, but not infant, CP epithelium is discussed in regard to ion transport, CSF secretion, intracranial pressure, and hydrocephalus.

cerebrospinal fluid homeostasis; chloride-36 efflux rate coefficient; hydrocephalus; V1 receptor antagonist; neuroendocrine regulation; arginine vasopressin


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
G. Nagra, L. Koh, A. Zakharov, D. Armstrong, and M. Johnston
Quantification of cerebrospinal fluid transport across the cribriform plate into lymphatics in rats
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2006; 291(5): R1383 - R1389.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. E. Johanson, J. Szmydynger-Chodobska, A. Chodobski, A. Baird, P. McMillan, and E. G. Stopa
Altered formation and bulk absorption of cerebrospinal fluid in FGF-2-induced hydrocephalus
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 1999; 277(1): R263 - R271.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online