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Department of Physiology and Biophysics, Department of Cell Biology, Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama 35294-0005
The concept that the cystic fibrosis (CF) transmembrane
conductance regulator, the protein product of the CF gene, can conduct larger multivalent anions such as ATP as well as
Cl
is controversial. In
this review, I examine briefly past findings that resulted in
controversy. It is not the goal of this review to revisit these
disparate findings in detail. Rather, I focus intently on more recent
studies, current studies in progress, and possible future directions
that arose from the controversy and that may reconcile this issue.
Important questions and hypotheses are raised as to the physiological
roles that ATP-binding cassette (ABC) transporter-facilitated ATP
transport and signaling may play in the control of epithelial cell
function. Perhaps the identification of key biological paradigms for
ABC transporter-mediated extracellular nucleotide signaling may unify
and guide the CF research community and other research groups
interested in ABC transporters toward understanding why ABC
transporters facilitate ATP transport.
cystic fibrosis transmembrane conductance regulator; multidrug resistance protein; P-glycoprotein; autocrine; paracrine; signaling; ion transport; cystic fibrosis; ATP-binding cassette
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