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1 Department of Pathology, Washington University School of Medicine, St. Louis, Missouri 63110; and 2 Nephrology Section, Department of Medicine, Veterans Affairs Medical Center, Bronx 10468; and Mount Sinai School of Medicine, New York, New York 10029
The K-Cl cotransporter protein KCC1 is a membrane transport protein that mediates the coupled, electroneutral transport of K and Cl across plasma membranes. The precise cell type(s) in the kidney that express the K-Cl cotransporter have remained unknown. The aim of the present investigation was to define the distribution of KCC1 mRNA in the human kidney. We used in situ hybridization with a nonradioactive digoxigenin-labeled riboprobe. We identified abundant KCC1 mRNA expression in the epithelial cells throughout the distal and proximal renal tubular epithelium. The transporter was also expressed in glomerular mesangial cells and endothelial cells of the renal vessels. These findings suggest that the K-Cl cotransporter may have an important role in transepithelial K and Cl reabsorption.
ion transport; cotransport; cell volume; cation-chloride cotransporter; furosemide; potassium chloride; gene expression
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