Am J Physiol Cell Physiol Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Cell Physiol 274: C1047-C1056, 1998;
0363-6143/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Amlal, H.
Right arrow Articles by Bichara, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Amlal, H.
Right arrow Articles by Bichara, M.
Vol. 274, Issue 4, C1047-C1056, April 1998

ANG II controls Na+-K+(NH+4)-2Clminus cotransport via 20-HETE and PKC in medullary thick ascending limb

Hassane Amlal1,2, Christian LeGoff1, Catherine Vernimmen1, Manoocher Soleimani2, Michel Paillard1, and Maurice Bichara1

1 Physiologie et Endocrinologie Cellulaire Rénale, Institut National de la Santé et de la Recherche Médicale Unité 356, Université Pierre et Marie Curie and Hôpital Broussais, 75270 Paris Cedex 06, France; and 2 Department of Internal Medicine and Molecular Genetics, University of Cincinnati School of Medicine, Cincinnati, Ohio 45267

Cell pH was monitored in medullary thick ascending limbs to determine effects of ANG II on Na+-K+(NH+4)-2Cl- cotransport. ANG II at 10-16 to 10-12 M inhibited 30-50% (P < 0.005), but higher ANG II concentrations were stimulatory compared with the 10-12 M ANG II level cotransport activity; eventually, 10-6 M ANG II stimulated 34% cotransport activity (P < 0.003). Inhibition by 10-12 M ANG II was abolished by phospholipase C (PLC), diacylglycerol lipase, or cytochrome P-450-dependent monooxygenase blockade; 10-12 M ANG II had no effect additive to inhibition by 20-hydroxyeicosatetranoic acid (20-HETE). Stimulation by 10-6 M ANG II was abolished by PLC and protein kinase C (PKC) blockade and was partially suppressed when the rise in cytosolic Ca2+ was prevented. All ANG II effects were abolished by DUP-753 (losartan) but not by PD-123319. Thus <= 10-12 M ANG II inhibits via 20-HETE, whereas >= 5 × 10-11 M ANG II stimulates via PKC Na+-K+(NH+4)-2Cl- cotransport; all ANG II effects involve AT1 receptors and PLC activation.

intracellular pH; intracellular calcium; cytochrome P-450-dependent monooxygenase; phospholipase C; diacylglycerol lipase; protein kinase C; angiotensin II receptors; DUP-753; PD-123319


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
A. M. Jensen, C. Li, H. A. Praetorius, R. Norregaard, S. Frische, M. A. Knepper, S. Nielsen, and J. Frokiaer
Angiotensin II mediates downregulation of aquaporin water channels and key renal sodium transporters in response to urinary tract obstruction
Am J Physiol Renal Physiol, November 1, 2006; 291(5): F1021 - F1032.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
T.-H. Kwon, J. Nielsen, M. A. Knepper, J. Frokiaer, and S. Nielsen
Angiotensin II AT1 receptor blockade decreases vasopressin-induced water reabsorption and AQP2 levels in NaCl-restricted rats
Am J Physiol Renal Physiol, April 1, 2005; 288(4): F673 - F684.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
N. Lerolle, S. Bourgeois, F. Leviel, G. Lebrun, M. Paillard, and P. Houillier
Angiotensin II inhibits NaCl absorption in the rat medullary thick ascending limb
Am J Physiol Renal Physiol, September 1, 2004; 287(3): F404 - F410.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. A. Dos Santos, A. J. Dahly-Vernon, K. M. Hoagland, and R. J. Roman
Inhibition of the formation of EETs and 20-HETE with 1-aminobenzotriazole attenuates pressure natriuresis
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2004; 287(1): R58 - R68.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
H. J. Han, S. H. Park, and Y. J. Lee
Signaling cascade of ANG II-induced inhibition of {alpha}-MG uptake in renal proximal tubule cells
Am J Physiol Renal Physiol, April 1, 2004; 286(4): F634 - F642.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
T.-H. Kwon, J. Nielsen, Y.-H. Kim, M. A. Knepper, J. Frokiaer, and S. Nielsen
Regulation of sodium transporters in the thick ascending limb of rat kidney: response to angiotensin II
Am J Physiol Renal Physiol, July 1, 2003; 285(1): F152 - F165.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. Yuan, M. Liang, Z. Yang, E. Rute, N. Taylor, M. Olivier, and A. W. Cowley Jr.
Gene expression reveals vulnerability to oxidative stress and interstitial fibrosis of renal outer medulla to nonhypertensive elevations of ANG II
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2003; 284(5): R1219 - R1230.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
D. Staahltoft, S. Nielsen, N. R. Janjua, S. Christensen, O. Skott, N. Marcussen, and T. E. N. Jonassen
Losartan treatment normalizes renal sodium and water handling in rats with mild congestive heart failure
Am J Physiol Renal Physiol, February 1, 2002; 282(2): F307 - F315.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
R. J. Roman
P-450 Metabolites of Arachidonic Acid in the Control of Cardiovascular Function
Physiol Rev, January 1, 2002; 82(1): 131 - 185.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. Charbonneau, M. Leclerc, and M. G. Brunette
Effect of angiotensin II on calcium reabsorption by the luminal membranes of the nephron
Am J Physiol Endocrinol Metab, June 1, 2001; 280(6): E928 - E936.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
E. Feraille and A. Doucet
Sodium-Potassium-Adenosinetriphosphatase-Dependent Sodium Transport in the Kidney: Hormonal Control
Physiol Rev, January 1, 2001; 81(1): 345 - 418.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. Attmane-Elakeb, H. Amlal, and M. Bichara
Ammonium carriers in medullary thick ascending limb
Am J Physiol Renal Physiol, January 1, 2001; 280(1): F1 - F9.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. Kato, J. D. Klein, C. Zhang, and J. M. Sands
Angiotensin II increases vasopressin-stimulated facilitated urea permeability in rat terminal IMCDs
Am J Physiol Renal Physiol, November 1, 2000; 279(5): F835 - F840.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
R. Quigley, M. Baum, K. M. Reddy, J. C. Griener, and J. R. Falck
Effects of 20-HETE and 19(S)-HETE on rabbit proximal straight tubule volume transport
Am J Physiol Renal Physiol, June 1, 2000; 278(6): F949 - F953.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. C. Frisbee, J. R. Falck, and J. H. Lombard
Contribution of cytochrome P-450 omega -hydroxylase to altered arteriolar reactivity with high-salt diet and hypertension
Am J Physiol Heart Circ Physiol, May 1, 2000; 278(5): H1517 - H1526.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
P. Christmas, J. P. Jones, C. J. Patten, D. A. Rock, Y. Zheng, S.-M. Cheng, B. M. Weber, N. Carlesso, D. T. Scadden, A. E. Rettie, et al.
Alternative Splicing Determines the Function of CYP4F3 by Switching Substrate Specificity
J. Biol. Chem., October 5, 2001; 276(41): 38166 - 38172.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
G. Kovacs, J. Peti-Peterdi, L. Rosivall, and P. D. Bell
Angiotensin II directly stimulates macula densa Na-2Cl-K cotransport via apical AT1 receptors
Am J Physiol Renal Physiol, February 1, 2002; 282(2): F301 - F306.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online