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Departments of 1 Biological Chemistry, 2 Plastic Surgery, and 3 Human Physiology, University of California, Davis, California 95616-8635
Gated
31P-nuclear magnetic resonance
followed the metabolic fluctuation in rat gastrocnemius muscle during a
contraction cycle. Within 16 ms after stimulation, the phosphocreatine
(PCr) level drops 11.3% from its reference state. The PCr minimum
corresponds closely to the time of maximum force contraction.
Pi increases stoichiometrically,
while ATP remains constant. During a twitch, PCr hydrolysis produces
3.1 µmol ATP/g tissue, which is substantially higher than the
reported 0.3 µmol
ATP · twitch
1 · g
tissue1 derived from
steady-state experiments. The results reveal that a substantial energy
fluctuation accompanies a muscle twitch.
nuclear magnetic resonance; metabolism; twitch; energetics
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