Am J Physiol Cell Physiol AJP: Lung Cellular and Molecular Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Cell Physiol 274: C810-C818, 1998;
0363-6143/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jaschinski, F.
Right arrow Articles by Pette, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jaschinski, F.
Right arrow Articles by Pette, D.
Vol. 274, Issue 3, C810-C818, March 1998

Sequential increases in capillarization and mitochondrial enzymes in low-frequency-stimulated rabbit muscle

Dejan Skorjanc, Frank Jaschinski, Georg Heine, and Dirk Pette

Faculty of Biology, University of Konstanz, D-78457 Constance, Germany

To investigate temporal changes in capillarization and increases in mitochondrial enzyme activity, rabbit tibialis anterior muscles underwent chronic low-frequency stimulation for up to 50 days. Capillary density (CD), capillary-to-fiber ratio (C/F), intercapillary distance (ICD), and mean capillary area (MCA), as well as several other parameters of capillarization, were examined. In addition, tissue levels of mRNA specific to vascular endothelial growth factor (VEGF) were assessed by reverse transcriptase-polymerase chain reaction. Citrate synthase (CS) activity, a marker of aerobic-oxidative metabolic potential, was measured in the same muscles. Significant increases in CD and C/F, respectively, and decreases in ICD and MCA were observed after 2 days. These changes reached stable maxima by 14 days. The increases in capillarization occurred in a fiber-type-specific manner, affecting type IId fibers before types IIda and IIa. VEGF mRNA levels increased in a bimodal time pattern with a first elevation (2.5-fold) after 1 day and a second (9-fold) after 6-8 days. Increases in CS were first noted after 8 days. Obviously, increases in capillarization as induced by enhanced contractile activity precede increases in the aerobic-oxidative potential of energy metabolism.

electrical stimulation; mitochondrial enzyme activity; morphometry; vascular endothelial growth factor


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
M. Milkiewicz, O. Hudlicka, M. D. Brown, and H. Silgram
Nitric oxide, VEGF, and VEGFR-2: interactions in activity-induced angiogenesis in rat skeletal muscle
Am J Physiol Heart Circ Physiol, July 1, 2005; 289(1): H336 - H343.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
I. Momken, P. Lechene, R. Ventura-Clapier, and V. Veksler
Voluntary physical activity alterations in endothelial nitric oxide synthase knockout mice
Am J Physiol Heart Circ Physiol, August 1, 2004; 287(2): H914 - H920.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
G. Chen, S. Carroll, P. Racay, J. Dick, D. Pette, I. Traub, G. Vrbova, P. Eggli, M. Celio, and B. Schwaller
Deficiency in parvalbumin increases fatigue resistance in fast-twitch muscle and upregulates mitochondria
Am J Physiol Cell Physiol, July 1, 2001; 281(1): C114 - C122.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. P. Gavin and P. D. Wagner
Effect of short-term exercise training on angiogenic growth factor gene responses in rats
J Appl Physiol, April 1, 2001; 90(4): 1219 - 1226.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. Pette
Plasticity in Skeletal, Cardiac, and Smooth Muscle: Historical Perspectives: Plasticity of mammalian skeletal muscle
J Appl Physiol, March 1, 2001; 90(3): 1119 - 1124.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. P. Gavin, D. A. Spector, H. Wagner, E. C. Breen, and P. D. Wagner
Nitric oxide synthase inhibition attenuates the skeletal muscle VEGF mRNA response to exercise
J Appl Physiol, April 1, 2000; 88(4): 1192 - 1198.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
H. Green, R. Tupling, B. Roy, D. O'Toole, M. Burnett, and S. Grant
Adaptations in skeletal muscle exercise metabolism to a sustained session of heavy intermittent exercise
Am J Physiol Endocrinol Metab, January 1, 2000; 278(1): E118 - E126.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
S. Carroll, P. Nicotera, and D. Pette
Calcium transients in single fibers of low-frequency stimulated fast-twitch muscle of rat
Am J Physiol Cell Physiol, December 1, 1999; 277(6): C1122 - C1129.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
T. Gustafsson, A. Puntschart, L. Kaijser, E. Jansson, and C. J. Sundberg
Exercise-induced expression of angiogenesis-related transcription and growth factors in human skeletal muscle
Am J Physiol Heart Circ Physiol, February 1, 1999; 276(2): H679 - H685.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online