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Am J Physiol Cell Physiol 274: C13-C23, 1998;
0363-6143/98 $5.00
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Vol. 274, Issue 1, C13-C23, January 1998

AJP CENTENNIAL
A century of (epithelial) transport physiology: from vitalism to molecular cloning

Stanley G. Schultz

Department of Integrative Biology and Pharmacology, University of Texas Medical School, Houston, Texas 77225

During the past century, the generally accepted view of the function of biological membranes has evolved from that of a static, inert lipoprotein envelope that simply separates the intracellular machinery from the outside milieu, to that of a dynamic structure that is, in fact, an integral part of that machinery actively involved in homeostasis and bioenergetics. This brief review traces that paradigm shift with special emphasis on the evolution of central concepts in epithelial transport physiology.

history; membrane physiology; absorption; secretion


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