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Am J Physiol Cell Physiol 273: C1416-C1426, 1997;
0363-6143/97 $5.00
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Vol. 273, Issue 4, C1416-C1426, October 1997

MODELING IN PHYSIOLOGY
Predicted changes in concentrations of free and bound ATP and ADP during intracellular Ca2+ signaling

M. E. Kargacin and G. J. Kargacin

Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada T2N 4N1

High Ca2+ concentrations can develop near Ca2+ sources during intracellular signaling and might lead to localized regulation of Ca2+-dependent processes. By shifting the amount of Ca2+ and other cations associated with ATP, local high Ca2+ concentrations might also alter the substrate available for membrane-associated and cytoplasmic enzymes. To study this, simultaneous equations were solved over a range of Ca2+ and Mg2+ concentrations to determine the general effects of Ca2+ on the concentrations of free and Ca2+- and Mg2+-bound forms of ATP. To obtain a more specific picture of the changes that might occur in smooth muscle cells, mathematical models of Ca2+ diffusion and regulation were used to predict the magnitude and time course of near-membrane Ca2+ transients and their effects on the free and bound forms of ATP near the membrane. The results of this work indicate that changes in free Ca2+ concentration over the range of 50 nM-100 µM would result in significant changes in free ATP concentration, MgATP concentration, and the CaATP-to-MgATP concentration ratio.

smooth muscle; striated muscle; computer modeling; calcium channels; restricted diffusion; adenosinetriphosphate-sensitive channels


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