Am J Physiol Cell Physiol Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Cell Physiol 273: C755-C789, 1997;
0363-6143/97 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Web of Science (201)
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Okada, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Okada, Y.

AJP - Cell Physiology, Vol 273, Issue 3 C755-C789, Copyright © 1997 by American Physiological Society

ARTICLES

Volume expansion-sensing outward-rectifier Cl- channel: fresh start to the molecular identity and volume sensor

Y. Okada
Department of Cellular and Molecular Physiology, National Institute for Physiological Sciences, Okazaki, Japan.

The maintenance of a constant volume in the face of extracellular and intracellular osmotic perturbation is essential for the normal function and survival of animal cells. Osmotically swollen cells restore their volume, exhibiting a regulatory volume decrease by releasing intracellular K+, Cl-, organic solutes, and obligated water. In many cell types, the volume regulatory effluxes of Cl- and some organic osmolytes are known to be induced by swelling-induced activation of anion channels that are characterized by their moderate outward rectification, cytosolic ATP dependency, and intermediate unitary conductance (10-100 pS). Recently, simultaneous measurements of cell size by light microscopy and whole cell Cl- current have shown that the Cl- current density is proportionally increased with an increase in the outer surface area, which is mainly achieved through unfolding of membrane invaginations by volume expansion. Thus this anion channel can somehow sense volume expansion and can be called the volume expansion-sensing outwardly rectifying (VSOR) anion channel. Its molecular identity and activation mechanism are yet to be elucidated. Three cloned proteins, ClC-2, P-glycoprotein, and pIcln, have been proposed as candidates for the VSOR anion channel. The unitary conductance, voltage dependency, anion selectivity, pH dependency, and pharmacology of the VSOR anion channel are distinct from the ClC-2 Cl- channel, which is also known to be sensitive to volume changes. Recent patch-clamp studies in combination with molecular biological techniques have shown that P-glycoprotein is not itself the channel protein but is a regulator of its volume sensitivity. Although there is still debate about another candidate protein, pIcln, the most recent study has suggested that this is likely to be a regulator of some other distinct Cl- channel. Identification of the VSOR anion channel protein per se, its volume-sensing mechanism, and its accessory/regulatory proteins at the molecular level is currently a subject of utmost physiological importance.


This article has been cited by other articles:


Home page
 HypertensionHome page
W. Liang, J. B. Ray, J. Z. He, P. H. Backx, and M. E. Ward
Regulation of Proliferation and Membrane Potential by Chloride Currents in Rat Pulmonary Artery Smooth Muscle Cells
Hypertension, August 1, 2009; 54(2): 286 - 293.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
H.-T. Liu, T. Akita, T. Shimizu, R. Z. Sabirov, and Y. Okada
Bradykinin-induced astrocyte\#8211;neuron signalling: glutamate release is mediated by ROS-activated volume-sensitive outwardly rectifying anion channels
J. Physiol., May 15, 2009; 587(10): 2197 - 2209.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
Y. Okada, K. Sato, and T. Numata
Pathophysiology and puzzles of the volume-sensitive outwardly rectifying anion channel
J. Physiol., May 15, 2009; 587(10): 2141 - 2149.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Avella, O. Ducoudret, D. F. Pisani, and P. Poujeol
Swelling-activated transport of taurine in cultured gill cells of sea bass: physiological adaptation and pavement cell plasticity
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2009; 296(4): R1149 - R1160.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
E. K. Hoffmann, I. H. Lambert, and S. F. Pedersen
Physiology of Cell Volume Regulation in Vertebrates
Physiol Rev, January 1, 2009; 89(1): 193 - 277.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
E. L. Lee, Y. Hasegawa, T. Shimizu, and Y. Okada
IK1 channel activity contributes to cisplatin sensitivity of human epidermoid cancer cells
Am J Physiol Cell Physiol, June 1, 2008; 294(6): C1398 - C1406.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
X. Yin, J. Denton, X. Yan, and K. Strange
Characterization of a novel voltage-dependent outwardly rectifying anion current in Caenorhabditis elegans oocytes
Am J Physiol Cell Physiol, January 1, 2007; 292(1): C269 - C277.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
T. K. Klausen, C. Hougaard, E. K. Hoffmann, and S. F. Pedersen
Cholesterol modulates the volume-regulated anion current in Ehrlich-Lettre ascites cells via effects on Rho and F-actin
Am J Physiol Cell Physiol, October 1, 2006; 291(4): C757 - C771.
[Abstract] [Full Text] [PDF]

Home page
 J. Physiol.Home page
I. F. Abdullaev, A. Rudkouskaya, G. P. Schools, H. K. Kimelberg, and A. A. Mongin
Pharmacological comparison of swelling-activated excitatory amino acid release and Cl- currents in cultured rat astrocytes
J. Physiol., May 1, 2006; 572(3): 677 - 689.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
S. J. Park, C. M. Mckay, Y. Zhu, and J. D. Huizinga
Volume-activated chloride currents in interstitial cells of Cajal
Am J Physiol Gastrointest Liver Physiol, November 1, 2005; 289(5): G791 - G797.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Z. Ren and C. M. Baumgarten
Antagonistic regulation of swelling-activated Cl- current in rabbit ventricle by Src and EGFR protein tyrosine kinases
Am J Physiol Heart Circ Physiol, June 1, 2005; 288(6): H2628 - H2636.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
D. M. Cohen
SRC family kinases in cell volume regulation
Am J Physiol Cell Physiol, March 1, 2005; 288(3): C483 - C493.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
A. A. Mongin and H. K. Kimelberg
ATP regulates anion channel-mediated organic osmolyte release from cultured rat astrocytes via multiple Ca2+-sensitive mechanisms
Am J Physiol Cell Physiol, January 1, 2005; 288(1): C204 - C213.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
M. Nobles, C. F. Higgins, and A. Sardini
Extracellular acidification elicits a chloride current that shares characteristics with ICl(swell)
Am J Physiol Cell Physiol, November 1, 2004; 287(5): C1426 - C1435.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
F. Okamoto, H. Kajiya, H. Fukushima, E. Jimi, and K. Okabe
Prostaglandin E2 activates outwardly rectifying Cl- channels via a cAMP-dependent pathway and reduces cell motility in rat osteoclasts
Am J Physiol Cell Physiol, July 1, 2004; 287(1): C114 - C124.
[Abstract] [Full Text] [PDF]

Home page
 JGPHome page
X.-L. Du, Z. Gao, C.-P. Lau, S.-W. Chiu, H.-F. Tse, C. M. Baumgarten, and G.-R. Li
Differential Effects of Tyrosine Kinase Inhibitors on Volume-sensitive Chloride Current in Human Atrial Myocytes: Evidence for Dual Regulation by Src and EGFR Kinases
J. Gen. Physiol., March 29, 2004; 123(4): 427 - 439.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
M. Hayashi, C. Kunii, T. Takahata, and T. Ishikawa
ATP-dependent regulation of SK4/IK1-like currents in rat submandibular acinar cells: possible role of cAMP-dependent protein kinase
Am J Physiol Cell Physiol, March 1, 2004; 286(3): C635 - C646.
[Abstract] [Full Text]

Home page
 J. Neurophysiol.Home page
A. A. Mongin, H. K. Kimelberg, and B. A. MacVicar
Is autocrine ATP release required for activation of volume-sensitive chloride channels?
J Neurophysiol, October 1, 2003; 90(4): 2791 - 2793.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G.-X. Wang, W. J. Hatton, G. L. Wang, J. Zhong, I. Yamboliev, D. Duan, and J. R. Hume
Functional effects of novel anti-ClC-3 antibodies on native volume-sensitive osmolyte and anion channels in cardiac and smooth muscle cells
Am J Physiol Heart Circ Physiol, October 1, 2003; 285(4): H1453 - H1463.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
Y. Li, S. T. Halm, and D. R. Halm
Secretory activation of basolateral membrane Cl- channels in guinea pig distal colonic crypts
Am J Physiol Cell Physiol, April 1, 2003; 284(4): C918 - C933.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
M. Sonoda, F. Okamoto, H. Kajiya, Y. Inoue, K. Honjo, Y. Sumii, T. Kawarabayashi, and K. Okabe
Amino Acid-Permeable Anion Channels in Early Mouse Embryos and Their Possible Effects on Cleavage
Biol Reprod, March 1, 2003; 68(3): 947 - 953.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. Wang, S. Morishima, and Y. Okada
IK channels are involved in the regulatory volume decrease in human epithelial cells
Am J Physiol Cell Physiol, January 1, 2003; 284(1): C77 - C84.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. Zhong, G.-X. Wang, W. J. Hatton, I. A. Yamboliev, M. P. Walsh, and J. R. Hume
Regulation of volume-sensitive outwardly rectifying anion channels in pulmonary arterial smooth muscle cells by PKC
Am J Physiol Cell Physiol, December 1, 2002; 283(6): C1627 - C1636.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. M. Fernandez-Fernandez, M. Nobles, A. Currid, E. Vazquez, and M. A. Valverde
Maxi K+ channel mediates regulatory volume decrease response in a human bronchial epithelial cell line
Am J Physiol Cell Physiol, December 1, 2002; 283(6): C1705 - C1714.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M.-R. Shen, C.-Y. Chou, K.-F. Hsu, and J. C. Ellory
Osmotic Shrinkage of Human Cervical Cancer Cells Induces an Extracellular Cl--dependent Nonselective Cation Channel, Which Requires p38 MAPK
J. Biol. Chem., November 22, 2002; 277(48): 45776 - 45784.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
D. Baev, X. S. Li, J. Dong, P. Keng, and M. Edgerton
Human Salivary Histatin 5 Causes Disordered Volume Regulation and Cell Cycle Arrest in Candida albicans
Infect. Immun., September 1, 2002; 70(9): 4777 - 4784.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
A. A. Mongin and H. K. Kimelberg
ATP potently modulates anion channel-mediated excitatory amino acid release from cultured astrocytes
Am J Physiol Cell Physiol, August 1, 2002; 283(2): C569 - C578.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
C. H. Mitchell, J. C. Fleischhauer, W. D. Stamer, K. Peterson-Yantorno, and M. M. Civan
Human trabecular meshwork cell volume regulation
Am J Physiol Cell Physiol, July 1, 2002; 283(1): C315 - C326.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M.-R. Shen, T.-P. Yang, and M.-J. Tang
A Novel Function of BCL-2 Overexpression in Regulatory Volume Decrease. ENHANCING SWELLING-ACTIVATED Ca2+ ENTRY AND Cl- CHANNEL ACTIVITY
J. Biol. Chem., May 3, 2002; 277(18): 15592 - 15599.
[Abstract] [Full Text] [PDF]

Home page
 IOVSHome page
C. Shi, S. Barnes, M. Coca-Prados, and M. E. M. Kelly
Protein Tyrosine Kinase and Protein Phosphatase Signaling Pathways Regulate Volume-Sensitive Chloride Currents in a Nonpigmented Ciliary Epithelial Cell Line
Invest. Ophthalmol. Vis. Sci., May 1, 2002; 43(5): 1525 - 1532.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
T. J. Jentsch, V. Stein, F. Weinreich, and A. A. Zdebik
Molecular Structure and Physiological Function of Chloride Channels
Physiol Rev, April 1, 2002; 82(2): 503 - 568.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. C. Fleischhauer, C. H. Mitchell, K. Peterson-Yantorno, M. Coca-Prados, and M. M. Civan
PGE2, Ca2+, and cAMP mediate ATP activation of Cl- channels in pigmented ciliary epithelial cells
Am J Physiol Cell Physiol, November 1, 2001; 281(5): C1614 - C1623.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
B. Nilius and G. Droogmans
Ion Channels and Their Functional Role in Vascular Endothelium
Physiol Rev, October 1, 2001; 81(4): 1415 - 1459.
[Abstract] [Full Text] [PDF]

Home page
 DevelopmentHome page
M. Kolajova, M.-A. Hammer, J. L. Collins, and J. M. Baltz
Developmentally regulated cell cycle dependence of swelling-activated anion channel activity in the mouse embryo
Development, September 15, 2001; 128(18): 3427 - 3434.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
A. Y. Estevez, T. Bond, and K. Strange
Regulation of ICl,swell in neuroblastoma cells by G protein signaling pathways
Am J Physiol Cell Physiol, July 1, 2001; 281(1): C89 - C98.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
D. Trouet, I. Carton, D. Hermans, G. Droogmans, B. Nilius, and J. Eggermont
Inhibition of VRAC by c-Src tyrosine kinase targeted to caveolae is mediated by the Src homology domains
Am J Physiol Cell Physiol, July 1, 2001; 281(1): C248 - C256.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
M. Bali, J. Lipecka, A. Edelman, and J. Fritsch
Regulation of ClC-2 chloride channels in T84 cells by TGF-{alpha}
Am J Physiol Cell Physiol, June 1, 2001; 280(6): C1588 - C1598.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
K. Kirk
Membrane Transport in the Malaria-Infected Erythrocyte
Physiol Rev, April 1, 2001; 81(2): 495 - 537.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
O. P. Hamill and B. Martinac
Molecular Basis of Mechanotransduction in Living Cells
Physiol Rev, April 1, 2001; 81(2): 685 - 740.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
F. C. Britton, W. J. Hatton, C. F. Rossow, D. Duan, J. R. Hume, and B. Horowitz
Molecular distribution of volume-regulated chloride channels (ClC-2 and ClC-3) in cardiac tissues
Am J Physiol Heart Circ Physiol, November 1, 2000; 279(5): H2225 - H2233.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
C. Maertens, L. Wei, G. Droogmans, and B. Nilius
Inhibition of Volume-Regulated and Calcium-Activated Chloride Channels by the Antimalarial Mefloquine
J. Pharmacol. Exp. Ther., October 1, 2000; 295(1): 29 - 36.
[Abstract] [Full Text]

Home page
 J. Neurosci.Home page
H. Morihata, F. Nakamura, T. Tsutada, and M. Kuno
Potentiation of a Voltage-Gated Proton Current in Acidosis-Induced Swelling of Rat Microglia
J. Neurosci., October 1, 2000; 20(19): 7220 - 7227.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
Y. M. Shuba, N. Prevarskaya, L. Lemonnier, F. Van Coppenolle, P. G. Kostyuk, B. Mauroy, and R. Skryma
Volume-regulated chloride conductance in the LNCaP human prostate cancer cell line
Am J Physiol Cell Physiol, October 1, 2000; 279(4): C1144 - C1154.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. A. Wittels, E. M. Hubert, M. W. Musch, and L. Goldstein
Osmolyte channel regulation by ionic strength in skate RBC
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2000; 279(1): R69 - R76.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
E. Scandella, U. O. Nagl, B. Oehl, F. Bergmann, M. Gschwentner, J. Furst, A. Schmarda, M. Ritter, S. Waldegger, F. Lang, et al.
The Promoter for Constitutive Expression of the Human ICln Gene CLNS1A
J. Biol. Chem., May 19, 2000; 275(21): 15613 - 15620.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
D. Duan, L. Ye, F. Britton, B. Horowitz, and J. R. Hume
A Novel Anionic Inward Rectifier in Native Cardiac Myocytes
Circ. Res., March 3, 2000; 86 (4): e63 - e71.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M.A. Hammer, M. Kolajova, M.-C. Leveille, P. Claman, and J.M. Baltz
Glycine transport by single human and mouse embryos
Hum. Reprod., February 1, 2000; 15(2): 419 - 426.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
J. R. Hume, D. Duan, M. L. Collier, J. Yamazaki, and B. Horowitz
Anion Transport in Heart
Physiol Rev, January 1, 2000; 80(1): 31 - 81.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
X. Meng and W. B. Reeves
Effects of chloride channel inhibitors on H2O2-induced renal epithelial cell injury
Am J Physiol Renal Physiol, January 1, 2000; 278(1): F83 - F90.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
M. Kawasaki, T. Fukuma, K. Yamauchi, H. Sakamoto, F. Marumo, and S. Sasaki
Identification of an acid-activated Cl- channel from human skeletal muscles
Am J Physiol Cell Physiol, November 1, 1999; 277(5): C948 - C954.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
A. A. Mongin, Z. Cai, and H. K. Kimelberg
Volume-dependent taurine release from cultured astrocytes requires permissive [Ca2+]i and calmodulin
Am J Physiol Cell Physiol, October 1, 1999; 277(4): C823 - C832.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
A. Stutzin, R. Torres, M. Oporto, P. Pacheco, A. L. Eguiguren, L. P. Cid, and F. V. Sepulveda
Separate taurine and chloride efflux pathways activated during regulatory volume decrease
Am J Physiol Cell Physiol, September 1, 1999; 277(3): C392 - C402.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
M. S. Herness and X.-D. Sun
Characterization of Chloride Currents and Their Noradrenergic Modulation in Rat Taste Receptor Cells
J Neurophysiol, July 1, 1999; 82(1): 260 - 271.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
A. A. Mongin, J. M. Reddi, C. Charniga, and H. K. Kimelberg
[3H]taurine and D-[3H]aspartate release from astrocyte cultures are differently regulated by tyrosine kinases
Am J Physiol Cell Physiol, May 1, 1999; 276(5): C1226 - C1230.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. J. Birdsey, R. D. H. Boyd, C. P. Sibley, and S. L. Greenwood
Effect of hyposmotic challenge on microvillous membrane potential in isolated human placental villi
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 1999; 276(5): R1479 - R1488.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
T. Voets, G. Droogmans, G. Raskin, J. Eggermont, and B. Nilius
Reduced intracellular ionic strength as the initial trigger for activation of endothelial volume-regulated anion channels
PNAS, April 27, 1999; 96(9): 5298 - 5303.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
L. Musante, O. Zegarra-Moran, P. G. Montaldo, M. Ponzoni, and L. J. V. Galietta
Autocrine Regulation of Volume-sensitive Anion Channels in Airway Epithelial Cells by Adenosine
J. Biol. Chem., April 23, 1999; 274(17): 11701 - 11707.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
I. A. Greenwood and W. A. Large
Properties of a Cl- current activated by cell swelling in rabbit portal vein vascular smooth muscle cells
Am J Physiol Heart Circ Physiol, November 1, 1998; 275(5): H1524 - H1532.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
G. M. Dick, K. K. Bradley, B. Horowitz, J. R. Hume, and K. M. Sanders
Functional and molecular identification of a novel chloride conductance in canine colonic smooth muscle
Am J Physiol Cell Physiol, October 1, 1998; 275(4): C940 - C950.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
G. Droogmans, J. Prenen, J. Eggermont, T. Voets, and B. Nilius
Voltage-dependent block of endothelial volume-regulated anion channels by calix[4]arenes
Am J Physiol Cell Physiol, September 1, 1998; 275(3): C646 - C652.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
R. W. Freel, M. Hatch, and N. D. Vaziri
Conductive pathways for chloride and oxalate in rabbit ileal brush-border membrane vesicles
Am J Physiol Cell Physiol, September 1, 1998; 275(3): C748 - C757.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
C.-J. C. Tang and T. K. Tang
The 30-kD Domain of Protein 4.1 Mediates Its Binding to the Carboxyl Terminus of pICln, a Protein Involved in Cellular Volume Regulation
Blood, August 15, 1998; 92(4): 1442 - 1447.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
Y. Liu, S. Oiki, T. Tsumura, T. Shimizu, and Y. Okada
Glibenclamide blocks volume-sensitive Cl- channels by dual mechanisms
Am J Physiol Cell Physiol, August 1, 1998; 275(2): C343 - C351.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
C. L. Cannon, S. Basavappa, and K. Strange
Intracellular ionic strength regulates the volume sensitivity of a swelling-activated anion channel
Am J Physiol Cell Physiol, August 1, 1998; 275(2): C416 - C422.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
E. M. Rutledge, M. Aschner, and H. K. Kimelberg
Pharmacological characterization of swelling-induced D-[3H]aspartate release from primary astrocyte cultures
Am J Physiol Cell Physiol, June 1, 1998; 274(6): C1511 - C1520.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
F. Emma, S. Breton, R. Morrison, S. Wright, and K. Strange
Effect of cell swelling on membrane and cytoplasmic distribution of pICln
Am J Physiol Cell Physiol, June 1, 1998; 274(6): C1545 - C1551.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
C. Lytle
A volume-sensitive protein kinase regulates the Na-K-2Cl cotransporter in duck red blood cells
Am J Physiol Cell Physiol, April 1, 1998; 274(4): C1002 - C1010.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
S. Basavappa, S. F. Pedersen, N. K. Jorgensen, J. C. Ellory, and E. K. Hoffmann
Swelling-Induced Arachidonic Acid Release via the 85-kDa cPLA2 in Human Neuroblastoma Cells
J Neurophysiol, March 1, 1998; 79(3): 1441 - 1449.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
F. LANG, G. L. BUSCH, M. RITTER, H. VOLKL, S. WALDEGGER, E. GULBINS, and D. HAUSSINGER
Functional Significance of Cell Volume Regulatory Mechanisms
Physiol Rev, January 1, 1998; 78(1): 247 - 306.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
H. Lock and M. A. Valverde
Contribution of the IsK (MinK) Potassium Channel Subunit to Regulatory Volume Decrease in Murine Tracheal Epithelial Cells
J. Biol. Chem., November 3, 2000; 275(45): 34849 - 34852.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
K.-H. Weylandt, M. A. Valverde, M. Nobles, S. Raguz, J. S. Amey, M. Diaz, C. Nastrucci, C. F. Higgins, and A. Sardini
Human ClC-3 Is Not the Swelling-activated Chloride Channel Involved in Cell Volume Regulation
J. Biol. Chem., May 11, 2001; 276(20): 17461 - 17467.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
M. Christensen and K. Strange
Developmental Regulation of a Novel Outwardly Rectifying Mechanosensitive Anion Channel in Caenorhabditis elegans
J. Biol. Chem., November 21, 2001; 276(48): 45024 - 45030.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
E. Maeno, Y. Ishizaki, T. Kanaseki, A. Hazama, and Y. Okada
From the Cover: Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis
PNAS, August 15, 2000; 97(17): 9487 - 9492.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
D. Salvail, M. Cloutier, and E. Rousseau
Functional reconstitution of an eicosanoid-modulated Cl- channel from bovine tracheal smooth muscle
Am J Physiol Cell Physiol, March 1, 2002; 282(3): C567 - C577.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
V. G. Romanenko, P. F. Davies, and I. Levitan
Dual effect of fluid shear stress on volume-regulated anion current in bovine aortic endothelial cells
Am J Physiol Cell Physiol, April 1, 2002; 282(4): C708 - C718.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
T. L. Yarbrough, T. Lu, H.-C. Lee, and E. F. Shibata
Localization of Cardiac Sodium Channels in Caveolin-Rich Membrane Domains: Regulation of Sodium Current Amplitude
Circ. Res., March 8, 2002; 90(4): 443 - 449.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online