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Am J Physiol Cell Physiol 271: C1957-C1962, 1996;
0363-6143/96 $5.00
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AJP - Cell Physiology, Vol 271, Issue 6 C1957-C1962, Copyright © 1996 by American Physiological Society

ARTICLES

Effects of taxol on isolated rat hepatocyte metabolism

A. Manzano, T. Roig, J. Bermudez and R. Bartrons
Unitat de Bioquimica, Unitat de Biofisica, Universitat de Barcelona, Spain.

Taxol is a natural product, isolated from Taxus brevifolia, with increasing clinical applications because of its potent antitumor activity. Although it is mainly metabolized in the liver, its effect on hepatocyte metabolism has been scarcely investigated. In this study, the response of isolated rat hepatocytes to taxol was evaluated by correlating the changes observed in global indexes such as viability and heat dissipation with those produced in oxygen consumption and intracellular metabolites (ATP, fructose 2,6-bisphosphate, and lactate). The results indicate that taxol reduces aerobic metabolism, which induces an insufficient increase of the ATP via anaerobic glycolysis. Moreover, incubations of isolated mitochondria with taxol indicate that the respiratory chain is directly affected by this drug.


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J. X. Perez, T. Roig, A. Manzano, M. Dalmau, J. Boada, F. Ventura, J. L. Rosa, J. Bermudez, and R. Bartrons
Overexpression of fructose 2,6-bisphosphatase decreases glycolysis and delays cell cycle progression
Am J Physiol Cell Physiol, November 1, 2000; 279(5): C1359 - C1365.
[Abstract] [Full Text] [PDF]


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