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Am J Physiol Cell Physiol 271: C863-C868, 1996;
0363-6143/96 $5.00
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AJP - Cell Physiology, Vol 271, Issue 3 C863-C868, Copyright © 1996 by American Physiological Society

ARTICLES

Temperature modulation of calcium channel function in GH3 cells

A. D. Rosen
Department of Neurology, School of Medicine, State University of New York, Stony Brook 11794-8121, USA.

The effect of temperature on calcium channel function was studied in GH3 cells, using the whole cell patch-clamp methodology. Specific parameters examined were peak current amplitude, activation time, and inactivation time. Over the temperature range studied (22-37 degree C), the peak current amplitude was found to be a non-linear function of temperature, with low-threshold currents more temperature dependent than high-threshold currents. Both activation time and inactivation time were faster at higher temperatures, but, whereas inactivation was a continuous function of temperature, activation was not, with a distinct discontinuity between 27 and 32 degrees C. These findings suggest that caution must be exercised in extrapolating data on channel function obtained at room temperature to physiological temperatures.


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