Am J Physiol Cell Physiol Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Cell Physiol 269: C1450-C1456, 1995;
0363-6143/95 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Stankovic, K. M.
Right arrow Articles by Brown, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Stankovic, K. M.
Right arrow Articles by Brown, D.

AJP - Cell Physiology, Vol 269, Issue 6 C1450-C1456, Copyright © 1995 by American Physiological Society

ARTICLES

Immunolocalization of aquaporin CHIP in the guinea pig inner ear

K. M. Stankovic, J. C. Adams and D. Brown
Division of Health Sciences and Technology, Harvard-Massachusetts Institute of Technology, Boston, USA.

Aquaporin CHIP (AQP-CHIP) is a water channel protein previously identified in red blood cells and water transporting epithelia. The inner ear is an organ of hearing and balance whose normal function depends critically on maintenance of fluid homeostasis. In this study, AQP-CHIP, or a close homologue, was found in specific cells of the inner ear, as assessed by immunocytochemistry with the use of affinity-purified polyclonal antibodies against AQP-CHIP.AQP-CHIP was predominantly found in fibrocytes in close association with bone, including most of the cells lining the bony labyrinth and in fibrocytes lining the endolymphatic duct and sac. AQP-CHIP-positive cells not directly apposing bone include cells under the basilar membrane, some type III fibrocytes of the spiral ligament, fibrocytes of the spiral limbus, and the trabecular perilymphatic tissue extending from the membranous to the bony labyrinth. AQP-CHIP was also found in the periosteum of the middle ear and cranial bones, as well as in chondrocytes of the oval window and stapes. The distribution of AQP-CHIP in the inner ear suggests that AQP-CHIP may have special significance for maintenance of bone and the basilar membrane, and for function of the spiral ligament.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Cell Physiol.Home page
F. Lang, V. Vallon, M. Knipper, and P. Wangemann
Functional significance of channels and transporters expressed in the inner ear and kidney
Am J Physiol Cell Physiol, October 1, 2007; 293(4): C1187 - C1208.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
B. Delprat, A. Boulanger, J. Wang, V. Beaudoin, M. J. Guitton, S. Venteo, C. J. Dechesne, R. Pujol, M. Lavigne-Rebillard, J.-L. Puel, et al.
Downregulation of Otospiralin, a Novel Inner Ear Protein, Causes Hair Cell Degeneration and Deafness
J. Neurosci., March 1, 2002; 22(5): 1718 - 1725.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurosci.Home page
I. A. Belyantseva, G. I. Frolenkov, J. B. Wade, F. Mammano, and B. Kachar
Water Permeability of Cochlear Outer Hair Cells: Characterization and Relationship to Electromotility
J. Neurosci., December 15, 2000; 20(24): 8996 - 9003.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Li and A. S. Verkman
Impaired Hearing in Mice Lacking Aquaporin-4 Water Channels
J. Biol. Chem., August 10, 2001; 276(33): 31233 - 31237.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online