Am J Physiol Cell Physiol AJP: Cell Physiology
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Am J Physiol Cell Physiol 269: C1305-C1310, 1995;
0363-6143/95 $5.00
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AJP - Cell Physiology, Vol 269, Issue 5 C1305-C1310, Copyright © 1995 by American Physiological Society

ARTICLES

Dexamethasone enhances expression of mitochondrial oxidative phosphorylation genes in rat distal colon

N. Rachamim, H. Latter, N. Malinin, C. Asher, H. Wald and H. Garty
Department of Membrane Research and Biophysics, Weizmann Institute of Science, Rehovot, Israel.

Dexamethasone and aldosterone are major activators of Na+ reabsorption in tight epithelia. The genes whose expression mediates the steroid actions are mostly unknown. To identify such genes, we performed differential screening of a rat colon cDNA library with total 32P-labeled cDNA probes reverse transcribed from steroid-stimulated and steroid-depleted poly(A)+ RNA. Several cDNAs whose corresponding mRNA is enhanced two- to threefold after dexamethasone injection were identified. Partial sequencing indicated that four of them code for subunits of cytochrome-c oxidase and 16S mitochondrial mRNA. The dexamethasone-induced increase in mitochondrial RNA abundance could not be mimicked by a low-salt diet, found to increase plasma aldosterone from 1.0 +/- 0.1 to 12.8 +/- 1.4 nM. Induction of mitochondrial genes by adrenal steroids may serve to prevent limitation of transport by the ATP supply to the Na(+)-K+ pump under conditions of maximal stimulation of Na+ transport.


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