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Am J Physiol Cell Physiol 269: C170-C178, 1995;
0363-6143/95 $5.00
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AJP - Cell Physiology, Vol 269, Issue 1 C170-C178, Copyright © 1995 by American Physiological Society

ARTICLES

K+ self-exchange by the Na+ pump: regulation by P(i) and metabolic perturbations

T. Nonaka, D. H. Warden, K. Matsushita and J. B. Stokes
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, USA.

We have previously demonstrated that the Na(+)-K+ pump on the basolateral membrane of the rabbit cortical collecting duct can function in the K+/K+ exchange mode. Increasing intracellular phosphate in red blood cells inhibits the Na+ pump and increases K+/K+ exchange. We found that maneuvers designed to increase intracellular phosphate in collecting duct cells caused an increase in K+/K+ exchange. Subjecting the cells to a metabolic insult (cyanide) increased K+/K+ exchange by the pump as judged by its ouabain sensitivity and lack of electrogenic or conductive characteristics. The results demonstrate that the rate of K+/K+ exchange by the Na(+)-K+ pump can be altered by changes in intracellular phosphate over a range that is physiologically or pathologically achievable. The results also suggest a mechanism for inhibition of vectorial Na+ transport during metabolic stress.


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