Am J Physiol Cell Physiol AJP: Cell Physiology
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Am J Physiol Cell Physiol 268: C918-C924, 1995;
0363-6143/95 $5.00
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AJP - Cell Physiology, Vol 268, Issue 4 C918-C924, Copyright © 1995 by American Physiological Society

ARTICLES

Regulation of skeletal alpha-actin promoter in young chickens during hypertrophy caused by stretch overload

J. A. Carson, Z. Yan, F. W. Booth, M. E. Coleman, R. J. Schwartz and C. S. Stump
Department of Physiology and Cell Biology, University of Texas-Houston Health Science Center, USA.

Anterior latissimus dorsi (ALD) muscles of 3-wk-old male chickens were injected with plasmids containing various lengths of the chicken skeletal alpha-actin promoter (ranging from -2,090 to -77 relative to the transcription start site) driving luciferase. Hypertrophy of the left ALD muscle was induced by attaching a weight (11% of body wt) to the left wing of each chicken, with the unweighted contralateral wing serving the control. Six days of stretch overload significantly increased muscle mass 110%. Luciferase activity from the -2,090 actin-luciferase chimeric gene increased 127% compared with the contralateral control ALD muscle. Luciferase activities driven by the -424, -202, and -99 actin promoters were 179, 134, and 378% higher, respectively, in the stretched ALD muscle than in the contralateral control ALD muscle. Luciferase activity from the -77 deletion construct was not different between stretched and control muscles. These data indicate that the gene region responding to stretch is downstream of -99 and imply, but do not conclusively prove, that the region between -99 and -77, which contains serum response element 1, contributes to the stretch-induced increase in skeletal alpha-actin promoter activity in the ALD muscle.


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