| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Cell Physiology, Vol 267, Issue 5 C1405-C1413, Copyright © 1994 by American Physiological Society
ARTICLES |
T. L. Cornwell, E. Arnold, N. J. Boerth and T. M. Lincoln
Department of Pathology, University of Alabama at Birmingham 35294-0019.
Recent studies indicate that nitric oxide (NO) and guanosine 3',5'-cyclic monophosphate (cGMP) may inhibit the proliferation of vascular smooth muscle cells (SMC) in vitro. The purpose of this study was to investigate the mechanism of NO- and cGMP-dependent inhibition of cultured rat aortic SMC. The cytokine interleukin-1 beta (IL-1 beta) inhibited serum- and platelet-derived growth factor-stimulated [3H]thymidine incorporation into DNA in subcultured rat aortic SMC. Incubation with IL-1 beta for 24 h markedly increased cGMP levels but not adenosine 3',5'-cyclic monophosphate (cAMP) levels. However, the IL-1 beta-induced increase in cGMP was correlated with an activation of the cAMP-dependent protein kinase (cAMP kinase) activity ratio. The activation of the cAMP kinase was prevented by treatments that blocked NO and cGMP production. The NO-generating vasodilator, S-nitroso-N-acetylpenicillamine (SNAP) also inhibited DNA synthesis and elevated cGMP levels. The inhibition of DNA synthesis by both IL-1 beta and SNAP was observed only when cGMP levels were elevated to high levels (10-fold or more). As was the case for IL-1 beta, SNAP increased the activity ratio of cAMP kinase. Selective inhibition of cAMP kinase using (R)-p-bromoadenosine 3',5'-cyclic monophosphorothioate prevented the inhibition of proliferation by IL-1 beta. By contrast, the inhibitor of the cGMP-dependent protein kinase, (R)-p-bromoguanosine 3',5'-cyclic monophosphorothioate, had no effect on IL-1 beta-induced inhibition of cellular proliferation. These studies suggest that cGMP-dependent activation of the cAMP kinase may be responsible in part at least for the NO-dependent inhibition of proliferation of subcultured rat aortic SMC.
This article has been cited by other articles:
|
|
 |
|
  A. Bouallegue, G. B. Daou, and A. K. Srivastava Nitric oxide attenuates endothelin-1-induced activation of ERK1/2, PKB, and Pyk2 in vascular smooth muscle cells by a cGMP-dependent pathway Am J Physiol Heart Circ Physiol, October 1, 2007; 293(4): H2072 - H2079. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Worner, R. Lukowski, F. Hofmann, and J. W. Wegener cGMP signals mainly through cAMP kinase in permeabilized murine aorta Am J Physiol Heart Circ Physiol, January 1, 2007; 292(1): H237 - H244. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. J. Busch, H. Liu, A. R. Graveline, and K. D. Bloch Nitric oxide induces phosphodiesterase 4B expression in rat pulmonary artery smooth muscle cells Am J Physiol Lung Cell Mol Physiol, April 1, 2006; 290(4): L747 - L753. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Hofmann, R. Feil, T. Kleppisch, and J. Schlossmann Function of cGMP-Dependent Protein Kinases as Revealed by Gene Deletion Physiol Rev, January 1, 2006; 86(1): 1 - 23. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Q. Zhang, M. Lazar, B. Molino, R. Rodriguez, T. Davidov, J. Su, J. Tse, H. R. Weiss, and P. M. Scholz Reduction in interaction between cGMP and cAMP in dog ventricular myocytes with hypertrophic failure Am J Physiol Heart Circ Physiol, September 1, 2005; 289(3): H1251 - H1257. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. J. Williams, D. G. Hemmings, J. M. Mitchell, I. C. McMillen, and S. T. Davidge Effects of maternal hypoxia or nutrient restriction during pregnancy on endothelial function in adult male rat offspring J. Physiol., May 15, 2005; 565(1): 125 - 135. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. C. Browner, H. Sellak, and T. M. Lincoln Downregulation of cGMP-dependent protein kinase expression by inflammatory cytokines in vascular smooth muscle cells Am J Physiol Cell Physiol, July 1, 2004; 287(1): C88 - C96. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Hamad, A. Clayton, B. Islam, and A. J. Knox Guanylyl cyclases, nitric oxide, natriuretic peptides, and airway smooth muscle function Am J Physiol Lung Cell Mol Physiol, November 1, 2003; 285(5): L973 - L983. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. Barman, S. Zhu, G. Han, and R. E. White cAMP activates BKCa channels in pulmonary arterial smooth muscle via cGMP-dependent protein kinase Am J Physiol Lung Cell Mol Physiol, June 1, 2003; 284(6): L1004 - L1011. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. M. D'Souza, R. L. Sparks, H. Chen, P. J. Kadowitz, and J. R. Jeter Jr. Mechanism of eNOS gene transfer inhibition of vascular smooth muscle cell proliferation Am J Physiol Cell Physiol, January 1, 2003; 284(1): C191 - C199. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Saksena, R. K. Gill, I. A. Syed, S. Tyagi, W. A. Alrefai, K. Ramaswamy, and P. K. Dudeja Modulation of Cl-/OH- exchange activity in Caco-2 cells by nitric oxide Am J Physiol Gastrointest Liver Physiol, September 1, 2002; 283(3): G626 - G633. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. K. Gill, S. Saksena, I. A. Syed, S. Tyagi, W. A. Alrefai, J. Malakooti, K. Ramaswamy, and P. K. Dudeja Regulation of NHE3 by nitric oxide in Caco-2 cells Am J Physiol Gastrointest Liver Physiol, September 1, 2002; 283(3): G747 - G756. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. J. Nathe, J. Deou, B. Walsh, B. Bourns, A. W. Clowes, and G. Daum Interleukin-1{beta} Inhibits Expression of p21(WAF1/CIP1) and p27(KIP1) and Enhances Proliferation in Response to Platelet-Derived Growth Factor-BB in Smooth Muscle Cells Arterioscler. Thromb. Vasc. Biol., August 1, 2002; 22(8): 1293 - 1298. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T Gewaltig and G. Kojda Vasoprotection by nitric oxide: mechanisms and therapeutic potential Cardiovasc Res, August 1, 2002; 55(2): 250 - 260. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. J. Simpson, I. Miller, C. Moon, A. L. Hanlon, D. J. Liebl, and G. V. Ronnett Atrial Natriuretic Peptide Type C Induces a Cell-Cycle Switch from Proliferation to Differentiation in Brain-Derived Neurotrophic Factor- or Nerve Growth Factor-Primed Olfactory Receptor Neurons J. Neurosci., July 1, 2002; 22(13): 5536 - 5551. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Sreejayan, Y. Lin, and A. Hassid NO Attenuates Insulin Signaling and Motility in Aortic Smooth Muscle Cells via Protein Tyrosine Phosphatase 1B-Mediated Mechanism Arterioscler. Thromb. Vasc. Biol., July 1, 2002; 22(7): 1086 - 1092. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. R. Standley, M. A. Stanley, and P. Senechal Activation of mitogenic and antimitogenic pathways in cyclically stretched arterial smooth muscle Am J Physiol Endocrinol Metab, December 1, 2001; 281(6): E1165 - E1171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. C. Berk Vascular Smooth Muscle Growth: Autocrine Growth Mechanisms Physiol Rev, July 1, 2001; 81(3): 999 - 1030. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P.-Y. von der Weid, J. Zhao, and D. F. Van Helden Nitric oxide decreases pacemaker activity in lymphatic vessels of guinea pig mesentery Am J Physiol Heart Circ Physiol, June 1, 2001; 280(6): H2707 - H2716. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. T. Osinski, B. H. Rauch, and K. Schrör Antimitogenic Actions of Organic Nitrates Are Potentiated by Sildenafil and Mediated Via Activation of Protein Kinase A Mol. Pharmacol., April 16, 2001; 59(5): 1044 - 1050. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. A. Dweik, D. Laskowski, M. Özkan, C. Farver, and S. C. Erzurum High Levels of Exhaled Nitric Oxide (NO) and NO Synthase III Expression in Lesional Smooth Muscle in Lymphangioleiomyomatosis Am. J. Respir. Cell Mol. Biol., April 1, 2001; 24(4): 414 - 418. [Abstract] [Full Text]
|
|
|
|
|
|
T. D. Le Cras and I. F. McMurtry Nitric oxide production in the hypoxic lung Am J Physiol Lung Cell Mol Physiol, April 1, 2001; 280(4): L575 - L582. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Burnett, A. Pung, J. S. Bertram, and R. V. Cooney The role of nitric oxide in neoplastic transformation of C3H 10T1/2 embryonic fibroblasts Carcinogenesis, November 1, 2000; 21(11): 1989 - 1995. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. R. Quinlan, D. Li, V. E. Laubach, E. G. Shesely, N. Zhou, and R. A. Johns eNOS-deficient mice show reduced pulmonary vascular proliferation and remodeling to chronic hypoxia Am J Physiol Lung Cell Mol Physiol, October 1, 2000; 279(4): L641 - L650. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. M. G. Verhagen, D. M. A. Attia, H. A. Koomans, and J. A. Joles Male gender increases sensitivity to proteinuria induced by mild NOS inhibition in rats: role of sex hormones Am J Physiol Renal Physiol, October 1, 2000; 279(4): F664 - F670. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Kalra, G. Baumgarten, Z. Dibbs, Y. Seta, N. Sivasubramanian, and D. L. Mann Nitric Oxide Provokes Tumor Necrosis Factor-{alpha} Expression in Adult Feline Myocardium Through a cGMP-Dependent Pathway Circulation, September 12, 2000; 102(11): 1302 - 1307. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Lucas, G. M. Pitari, S. Kazerounian, I. Ruiz-Stewart, J. Park, S. Schulz, K. P. Chepenik, and S. A. Waldman Guanylyl Cyclases and Signaling by Cyclic GMP Pharmacol. Rev., September 1, 2000; 52(3): 375 - 414. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Agata, R. Q. Miao, K. Yayama, L. Chao, and J. Chao Bradykinin B1 Receptor Mediates Inhibition of Neointima Formation in Rat Artery After Balloon Angioplasty Hypertension, September 1, 2000; 36(3): 364 - 370. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Sandirasegarane, R. Charles, N. Bourbon, and M. Kester NO regulates PDGF-induced activation of PKB but not ERK in A7r5 cells: implications for vascular growth arrest Am J Physiol Cell Physiol, July 1, 2000; 279(1): C225 - C235. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. D. Rudic, M. Bucci, D. Fulton, S. S. Segal, and W. C. Sessa Temporal Events Underlying Arterial Remodeling After Chronic Flow Reduction in Mice : Correlation of Structural Changes With a Deficit in Basal Nitric Oxide Synthesis Circ. Res., June 9, 2000; 86(11): 1160 - 1166. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. N. Dhanakoti, Y. Gao, M. Q. Nguyen, and J. U. Raj Involvement of cGMP-dependent protein kinase in the relaxation of ovine pulmonary arteries to cGMP and cAMP J Appl Physiol, May 1, 2000; 88(5): 1637 - 1642. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. White, J. P. Kryman, A. M. El-Mowafy, G. Han, and G. O. Carrier cAMP-Dependent Vasodilators Cross-Activate the cGMP-Dependent Protein Kinase to Stimulate BKCa Channel Activity in Coronary Artery Smooth Muscle Cells Circ. Res., April 28, 2000; 86(8): 897 - 905. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Li, S. Yang, and T. R. Billiar Cyclic Nucleotides Suppress Tumor Necrosis Factor alpha -Mediated Apoptosis by Inhibiting Caspase Activation and Cytochrome c Release in Primary Hepatocytes via a Mechanism Independent of Akt Activation J. Biol. Chem., April 21, 2000; 275(17): 13026 - 13034. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gu, J. Lynch, and P. Brecher Nitric Oxide Increases p21Waf1/Cip1 Expression by a cGMP-dependent Pathway That Includes Activation of Extracellular Signal-regulated Kinase and p70S6k J. Biol. Chem., April 6, 2000; 275(15): 11389 - 11396. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Ishigami, D. K. Swertfeger, M. S. Hui, N. A. Granholm, and D. Y. Hui Apolipoprotein E Inhibition of Vascular Smooth Muscle Cell Proliferation but Not the Inhibition of Migration Is Mediated Through Activation of Inducible Nitric Oxide Synthase Arterioscler. Thromb. Vasc. Biol., April 1, 2000; 20(4): 1020 - 1026. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pedram, M. Razandi, J. Kehrl, and E. R. Levin Natriuretic Peptides Inhibit G Protein Activation. MEDIATION THROUGH CROSS-TALK BETWEEN CYCLIC GMP-DEPENDENT PROTEIN KINASE AND REGULATORS OF G PROTEIN-SIGNALING PROTEINS J. Biol. Chem., March 15, 2000; 275(10): 7365 - 7372. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Gu and P. Brecher Nitric Oxide-Induced Increase in p21Sdi1/Cip1/Waf1 Expression During the Cell Cycle in Aortic Adventitial Fibroblasts Arterioscler. Thromb. Vasc. Biol., January 1, 2000; 20(1): 27 - 34. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Komalavilas, P. K. Shah, H. Jo, and T. M. Lincoln Activation of Mitogen-activated Protein Kinase Pathways by Cyclic GMP and Cyclic GMP-dependent Protein Kinase in Contractile Vascular Smooth Muscle Cells J. Biol. Chem., November 26, 1999; 274(48): 34301 - 34309. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Yamamoto, M. Aoyagi, N. Fukai, Y. Matsushima, and K. Yamamoto Increase in Prostaglandin E2 Production by Interleukin-1{beta} in Arterial Smooth Muscle Cells Derived From Patients With Moyamoya Disease Circ. Res., November 12, 1999; 85(10): 912 - 918. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Ishida, T. Sasaguri, Y. Miwa, C. Kosaka, Y. Taba, and T. Abumiya Tumor Suppressor p53 But Not cGMP Mediates NO-Induced Expression of p21Waf1/Cip1/Sdi1 in Vascular Smooth Muscle Cells Mol. Pharmacol., November 1, 1999; 56(5): 938 - 946. [Abstract] [Full Text]
|
|
|
|
|
|
A. L. Cooper and D. Beasley Hypoxia stimulates proliferation and interleukin-1alpha production in human vascular smooth muscle cells Am J Physiol Heart Circ Physiol, October 1, 1999; 277(4): H1326 - H1337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Gao, S. Dhanakoti, J.-F. Tolsa, and J. U. Raj Role of protein kinase G in nitric oxide- and cGMP-induced relaxation of newborn ovine pulmonary veins J Appl Physiol, September 1, 1999; 87(3): 993 - 998. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. J. Lalli, S. Shimizu, R. L. Sutliff, E. G. Kranias, and R. J. Paul [Ca2+]i homeostasis and cyclic nucleotide relaxation in aorta of phospholamban-deficient mice Am J Physiol Heart Circ Physiol, September 1, 1999; 277(3): H963 - H970. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Hassid, J. Yao, and S. Huang NO alters cell shape and motility in aortic smooth muscle cells via protein tyrosine phosphatase 1B activation Am J Physiol Heart Circ Physiol, September 1, 1999; 277(3): H1014 - H1026. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Ruiz, M. Del Rio, B. Somoza, P. Ganado, M. Sanz, and T. Tejerina L-Citrulline, the By-Product of Nitric Oxide Synthesis, Decreases Vascular Smooth Muscle Cell Proliferation J. Pharmacol. Exp. Ther., July 1, 1999; 290(1): 310 - 313. [Abstract] [Full Text]
|
|
|
|
|
|
K. B. Jourdan, T. W. Evans, N. J. Lamb, P. Goldstraw, and J. A. Mitchell Autocrine Function of Inducible Nitric Oxide Synthase and Cyclooxygenase-2 in Proliferation of Human and Rat Pulmonary Artery Smooth-Muscle Cells . Species Variation Am. J. Respir. Cell Mol. Biol., July 1, 1999; 21(1): 105 - 110. [Abstract] [Full Text]
|
|
|
|
 |
|
 M. E. Mendelsohn and R. H. Karas The Protective Effects of Estrogen on the Cardiovascular System N. Engl. J. Med., June 10, 1999; 340(23): 1801 - 1811. [Full Text] [PDF]
|
|
|
|
|
|
D. Beasley and A. L. Cooper Constitutive expression of interleukin-1alpha precursor promotes human vascular smooth muscle cell proliferation Am J Physiol Heart Circ Physiol, March 1, 1999; 276(3): H901 - H912. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Van Assche, I. Depoortere, R. De Vos, K. Geboes, J. J. Janssens, S. M. Collins, and T. L. Peeters Region-specific antiproliferative effect of VIP and PACAP-(1---38) on rabbit enteric smooth muscle Am J Physiol Gastrointest Liver Physiol, January 1, 1999; 276(1): G303 - G310. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J.-D. Chiche, S. M. Schlutsmeyer, D. B. Bloch, S. M. de la Monte, J. D. Roberts Jr., G. Filippov, S. P. Janssens, A. Rosenzweig, and K. D. Bloch Adenovirus-mediated Gene Transfer of cGMP-dependent Protein Kinase Increases the Sensitivity of Cultured Vascular Smooth Muscle Cells to the Antiproliferative and Pro-apoptotic Effects of Nitric Oxide/cGMP J. Biol. Chem., December 18, 1998; 273(51): 34263 - 34271. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Katsuyama, M. Shichiri, F. Marumo, and Y. Hirata NO Inhibits Cytokine-Induced iNOS Expression and NF-{kappa}B Activation by Interfering With Phosphorylation and Degradation of I{kappa}B-{alpha} Arterioscler. Thromb. Vasc. Biol., November 1, 1998; 18(11): 1796 - 1802. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. M. Buga, L. H. Wei, P. M. Bauer, J. M. Fukuto, and L. J. Ignarro NG-hydroxy-L-arginine and nitric oxide inhibit Caco-2 tumor cell proliferation by distinct mechanisms Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1998; 275(4): R1256 - R1264. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Hood and H. J. Granger Protein Kinase G Mediates Vascular Endothelial Growth Factor-induced Raf-1 Activation and Proliferation in Human Endothelial Cells J. Biol. Chem., September 4, 1998; 273(36): 23504 - 23508. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Braun-Dullaeus, M. J. Mann, and V. J. Dzau Cell Cycle Progression : New Therapeutic Target for Vascular Proliferative Disease Circulation, July 7, 1998; 98(1): 82 - 89. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. M. Bingisser, P. A. Tilbrook, P. G. Holt, and U. R. Kees Macrophage-Derived Nitric Oxide Regulates T Cell Activation via Reversible Disruption of the Jak3/STAT5 Signaling Pathway J. Immunol., June 15, 1998; 160(12): 5729 - 5734. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Yamamoto, M. Aoyagi, N. Fukai, Y. Matsushima, and K. Yamamoto Differences in Cellular Responses to Mitogens in Arterial Smooth Muscle Cells Derived From Patients With Moyamoya Disease Stroke, June 1, 1998; 29(6): 1188 - 1193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J o. Koglin, T. Glysing-Jensen, J. S. Mudgett, and M. E. Russell Exacerbated Transplant Arteriosclerosis in Inducible Nitric Oxide–Deficient Mice Circulation, May 26, 1998; 97(20): 2059 - 2065. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. Estevez, N. Spear, J. A. Thompson, T. L. Cornwell, R. Radi, L. Barbeito, and J. S. Beckman Nitric Oxide-Dependent Production of cGMP Supports the Survival of Rat Embryonic Motor Neurons Cultured with Brain-Derived Neurotrophic Factor J. Neurosci., May 15, 1998; 18(10): 3708 - 3714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Chen, G. Daum, R. Forough, M. Clowes, U. Walter, and A. W. Clowes Overexpression of Human Endothelial Nitric Oxide Synthase in Rat Vascular Smooth Muscle Cells and in Balloon-Injured Carotid Artery Circ. Res., May 4, 1998; 82(8): 862 - 870. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
|
