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Am J Physiol Cell Physiol 267: C920-C925, 1994;
0363-6143/94 $5.00
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AJP - Cell Physiology, Vol 267, Issue 4 C920-C925, Copyright © 1994 by American Physiological Society

ARTICLES

Depletion of intracellular Ca2+ stores activates a Ca(2+)-selective channel in vascular endothelium

L. Vaca and D. L. Kunze
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030.

The present study was designed to identify the channel responsible for Ca2+ influx after depletion of intracellular Ca2+ stores. Different maneuvers that deplete intracellular Ca2+ stores activated a Ca(2+)-selective channel. Superfusion of single bovine aortic endothelial cells with 50 nmol/l bradykinin, 10 mumol/l ATP, or 10 mumol/l 2,5-di(tert-butyl)-1,4-benzohydroquinone produced activation of channels of the same amplitude in cell-attached patches. Channel activity declined within the first minute after patch excision. The channel showed strong inward rectification and a reversal potential of 0 mV in symmetrical sodium sulfate (Na2SO4) solution. Under these conditions, the conductance was 5 pS in the inward direction. Addition of 10 mmol/l Ca2+ to the extracellular solution shifted the reversal potential to +30 +/- 5 mV, and the conductance for inward current was 11 pS. The reversal potential was used to calculate an ion permeability ratio of Ca2+/Na+ > 10:1.


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