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Am J Physiol Cell Physiol 267: C865-C868, 1994;
0363-6143/94 $5.00
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AJP - Cell Physiology, Vol 267, Issue 3 C865-C868, Copyright © 1994 by American Physiological Society

ARTICLES

Clenbuterol, a beta 2-agonist, retards wasting and loss of contractility in irradiated dystrophic mdx muscle

R. J. Zeman, Y. Zhang and J. D. Etlinger
Department of Cell Biology and Anatomy, New York Medical College, Valhalla 10595.

Treatment with the adrenergic beta 2-receptor agonist clenbuterol prevented, in dystrophic muscle from mdx mice, a pronounced loss of contractile strength that is observed after blockade of muscle regeneration with gamma irradiation. In addition, muscle mass and myosin content were greater (62-109%) in irradiated hindlimbs from clenbuterol-treated mdx mice, whereas the effects of the beta 2-agonist were relatively smaller (12-21%) in the nonirradiated hindlimbs. Together, these results suggest that beta 2-agonists can antagonize degenerative processes occurring in muscle fibers lacking dystrophin.


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