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Am J Physiol Cell Physiol 266: C1577-C1585, 1994;
0363-6143/94 $5.00
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AJP - Cell Physiology, Vol 266, Issue 6 C1577-C1585, Copyright © 1994 by American Physiological Society

ARTICLES

Anion-induced dynamic behavior of apical water channels in vasopressin-sensitive epithelia exposed to mercury

A. Grosso, P. Jaquet, P. Brawand and R. C. De Sousa
Department of Physiology, Centre Medical Universitaire, Geneva, Switzerland.

We showed recently that, in toad skins preexposed to Hg, water permeability is high in SO4-Ringer and low in Cl-Ringer. This anion effect was further investigated in Hg-treated skins and bladders of toads (Bufo marinus) in a variety of experimental conditions, including glutaraldehyde fixation and stimulation by vasopressin (VP) or isoproterenol (IP). In fixed bladders either unstimulated or stimulated with VP, net water flow (Jw) in SO4-Ringer [Jw (SO4)] was always significantly higher than Jw in Cl [Jw (Cl)]; the same applies to fixed toad skins, either unstimulated or stimulated with IP. In unfixed isolated toad epidermis challenged with IP before Hg exposure, Jw(SO4)/Jw(Cl) >> 1 approaching the ratio Jw (maximally stimulated)/Jw (basal). Therefore, anion-induced Jw changes were present whether Hg acted on epithelial water channels exocytosed by Hg itself or by hydrosomotic agents and suggest a switching between open and closed configurations of the channel protein. This anion effect was not abolished by glutaraldehyde and might be correlated with changes in intracellular chloride.


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