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Am J Physiol Cell Physiol 265: C1511-C1516, 1993;
0363-6143/93 $5.00
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AJP - Cell Physiology, Vol 265, Issue 6 C1511-C1516, Copyright © 1993 by American Physiological Society

ARTICLES

RNA subunit of mitochondrial RNA-processing enzyme is induced by contractile activity in striated muscle

G. A. Ordway, K. Li, G. A. Hand and R. S. Williams
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-8573.

A small RNA encoded within the nucleus of yeast and mammalian cells is an essential subunit of a mitochondrial RNA-processing endonuclease (RNase MRP) that generates primers for mitochondrial DNA (mtDNA) replication. We examined expression of MRP-RNA in specialized subtypes of mammalian striated muscles that differ markedly in respiratory activity and in muscles subjected to chronic stimulation via the motor nerve, a potent stimulus to mitochondrial biogenesis. MRP-RNA was more abundant in mitochondria-rich cardiac and slow-twitch skeletal muscles than in glycolytic fast-twitch skeletal muscles. Forced contractile activity resulting from nerve stimulation increased expression of MRP-RNA by 3.5-fold within the first day and by 14-fold within 14 days. Changes in abundance of MRP-RNA preceded but otherwise occurred in parallel to changes in specific activity of citrate synthase, a marker of mitochondrial proliferation shown previously to correlate with mtDNA copy number in this model. Another small RNA (U1) also was induced transiently (1-3 days) by nerve stimulation, but such changes were not sustained and were of less magnitude (< 4-fold) than changes in MRP-RNA. These findings are consistent with the hypothesis that MRP-RNA may have a regulatory function with respect to mtDNA replication and mitochondrial biogenesis.


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