| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Cell Physiology, Vol 265, Issue 4 C1006-C1014, Copyright © 1993 by American Physiological Society
ARTICLES |
O. Bussolati, R. Sala, A. Astorri, B. M. Rotoli, V. Dall'Asta and G. C. Gazzola
Istituto di Patologia Generale, Universita degli Studi di Parma, Italy.
The transport of amino acids has been studied in human umbilical vein endothelial cells. Neutral amino acids enter human umbilical vein endothelial cells through three distinct agencies endowed with the characteristics of systems A, ASC, and L. Each system has been studied by evaluating the influx of preferential substrates. The influx of L-proline and 2-methylaminoisobutyric acid occurs through an Na(+)-dependent adaptively regulated trans-inhibited agency identifiable with system A. L-Threonine influx occurs mainly through a distinct Na(+)-dependent trans-stimulated pathway corresponding to system ASC. System L accounts for Na(+)-independent influx of L-leucine. These systems cooperate for the transport of L-glutamine, which is due mainly to system ASC, whereas the component due to the operation of system A increases upon amino acid starvation. No clear evidence was found for a glutamine-specific system ("system N"). Two systems, one Na+ dependent (system XAG-) and the other Na+ independent (system xc-), transport anionic amino acids. L-Arginine influx exhibits a poor dependence on extracellular Na+, whereas it is sensitive to conditions known to change membrane potential and to trans-stimulation by intracellular amino acids. These features are consistent with a process mediated by system y+ and may be of significance for the regulation of the intracellular concentration of L-arginine.
This article has been cited by other articles:
|
|
 |
|
  G. E. Mann, D. L. Yudilevich, and L. Sobrevia Regulation of Amino Acid and Glucose Transporters in Endothelial and Smooth Muscle Cells Physiol Rev, January 1, 2003; 83(1): 183 - 252. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. W. WYATT, J. R. STEINERT, C. P. D. WHEELER-JONES, A. J. MORGAN, D. SUGDEN, J. D. PEARSON, L. SOBREVIA, and G. E. MANN Early activation of the p42/p44MAPK pathway mediates adenosine-induced nitric oxide production in human endothelial cells: a novel calcium-insensitive mechanism FASEB J, October 1, 2002; 16(12): 1584 - 1594. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Sala, B. M. Rotoli, E. Colla, R. Visigalli, A. Parolari, O. Bussolati, G. C. Gazzola, and V. Dall'Asta Two-way arginine transport in human endothelial cells: TNF-alpha stimulation is restricted to system y+ Am J Physiol Cell Physiol, January 1, 2002; 282(1): C134 - C143. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. P. Bode Recent Molecular Advances in Mammalian Glutamine Transport J. Nutr., September 1, 2001; 131(9): 2475S - 2485. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.-G. Petronini, R. R. Alfieri, M. N. Losio, A. E. Caccamo, A. Cavazzoni, M. A. Bonelli, A. F. Borghetti, and K. P. Wheeler Induction of BGT-1 and amino acid System A transport activities in endothelial cells exposed to hyperosmolarity Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2000; 279(5): R1580 - R1589. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Dall'Asta, O. Bussolati, R. Sala, A. Parolari, F. Alamanni, P. Biglioli, and G. C. Gazzola Amino acids are compatible osmolytes for volume recovery after hypertonic shrinkage in vascular endothelial cells Am J Physiol Cell Physiol, April 1, 1999; 276(4): C865 - C872. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Lohmann, W. W. Souba, and B. P. Bode Rat liver endothelial cell glutamine transporter and glutaminase expression contrast with parenchymal cells Am J Physiol Gastrointest Liver Physiol, March 1, 1999; 276(3): G743 - G750. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. D. S. Frame Conducted signals within arteriolar networks initiated by bioactive amino acids Am J Physiol Heart Circ Physiol, March 1, 1999; 276(3): H1012 - H1021. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W.-J. Lee, R. A. Hawkins, J. R. Vina, and D. R. Peterson Glutamine transport by the blood-brain barrier: a possible mechanism for nitrogen removal Am J Physiol Cell Physiol, April 1, 1998; 274(4): C1101 - C1107. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. K. McDonald, S. Zharikov, E. R. Block, and M. S. Kilberg A Caveolar Complex between the Cationic Amino Acid Transporter 1 and Endothelial Nitric-oxide Synthase May Explain the "Arginine Paradox" J. Biol. Chem., December 12, 1997; 272(50): 31213 - 31216. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. M. Pieper and L. A. Dondlinger Plasma and Vascular Tissue Arginine Are Decreased in Diabetes: Acute Arginine Supplementation Restores Endothelium-Dependent Relaxation by Augmenting cGMP Production J. Pharmacol. Exp. Ther., November 1, 1997; 283(2): 684 - 691. [Abstract] [Full Text]
|
|
|
|
|
|
W. W. Simmons, D. Ungureanu-Longrois, G. K. Smith, T. W. Smith, and R. A. Kelly Glucocorticoids Regulate Inducible Nitric Oxide Synthase by Inhibiting Tetrahydrobiopterin Synthesis and L-Arginine Transport J. Biol. Chem., September 27, 1996; 271(39): 23928 - 23937. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Wasa, H.-S. Wang, and A. Okada Characterization of L-glutamine transport by a human neuroblastoma cell line Am J Physiol Cell Physiol, June 1, 2002; 282(6): C1246 - C1253. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
