Am J Physiol Cell Physiol  AJP: Regulatory, Integrative and Comparative Physiology
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Am J Physiol Cell Physiol 265: C577-C606, 1993;
0363-6143/93 $5.00
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AJP - Cell Physiology, Vol 265, Issue 3 C577-C606, Copyright © 1993 by American Physiological Society


ARTICLES

Signal transduction via P2-purinergic receptors for extracellular ATP and other nucleotides

G. R. Dubyak and C. el-Moatassim
Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106.

Extracellular ATP, at micromolar concentrations, induces significant functional changes in a wide variety of cells and tissues. ATP can be released from the cytosol of damaged cells or from exocytotic vesicles and/or granules contained in many types of secretory cells. There are also efficient extracellular mechanisms for the rapid metabolism of released nucleotides by ecto-ATPases and 5'-nucleotidases. The diverse biological responses to ATP are mediated by a variety of cell surface receptors that are activated when ATP or other nucleotides are bound. The functionally identified nucleotide or P2-purinergic receptors include 1) ATP receptors that stimulate G protein-coupled effector enzymes and signaling cascades, including inositol phospholipid hydrolysis and the mobilization of intracellular Ca2+ stores; 2) ATP receptors that directly activate ligand-gated cation channels in the plasma membranes of many excitable cell types; 3) ATP receptors that, via the rapid induction of surface membrane channels and/or pores permeable to ions and endogenous metabolites, produce cytotoxic or activation responses in macrophages and other immune effector cells; and 4) ADP receptors that trigger rapid ion fluxes and aggregation responses in platelets. Current research in this area is directed toward the identification and structural characterization of these receptors by biochemical and molecular biological approaches.


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Am. J. Physiol. Cell Physiol.Home page
R. Coutinho-Silva, J.-L. Perfettini, P. M. Persechini, A. Dautry-Varsat, and D. M. Ojcius
Modulation of P2Z/P2X7 receptor activity in macrophages infected with Chlamydia psittaci
Am J Physiol Cell Physiol, January 1, 2001; 280(1): C81 - C89.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
R. D. Beigi and G. R. Dubyak
Endotoxin Activation of Macrophages Does Not Induce ATP Release and Autocrine Stimulation of P2 Nucleotide Receptors
J. Immunol., December 15, 2000; 165(12): 7189 - 7198.
[Abstract] [Full Text] [PDF]


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J. Pharmacol. Exp. Ther.Home page
G. Burnstock and M. Williams
P2 Purinergic Receptors: Modulation of Cell Function and Therapeutic Potential
J. Pharmacol. Exp. Ther., December 1, 2000; 295(3): 862 - 869.
[Full Text]


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J. Immunol.Home page
M. Schnurr, F. Then, P. Galambos, C. Scholz, B. Siegmund, S. Endres, and A. Eigler
Extracellular ATP and TNF-{alpha} Synergize in the Activation and Maturation of Human Dendritic Cells
J. Immunol., October 15, 2000; 165(8): 4704 - 4709.
[Abstract] [Full Text] [PDF]


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MicrobiologyHome page
O. Zaborina, N. Dhiman, M. Ling Chen, J. Kostal, I. A. Holder, and A. M. Chakrabarty
Secreted products of a nonmucoid Pseudomonas aeruginosa strain induce two modes of macrophage killing: external-ATP-dependent, P2Z-receptor-mediated necrosis and ATP-independent, caspase-mediated apoptosis
Microbiology, October 1, 2000; 146(10): 2521 - 2530.
[Abstract] [Full Text]


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FASEB J.Home page
G. HASKÓ, D. G. KUHEL, J.-F. CHEN, M. A. SCHWARZSCHILD, E. A. DEITCH, J. G. MABLEY, A. MARTON, and C. SZABÓ
Adenosine inhibits IL-12 and TNF-{alpha} production via adenosine A2a receptor-dependent and independent mechanisms
FASEB J, October 1, 2000; 14(13): 2065 - 2074.
[Abstract] [Full Text]


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Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
E. O. Harrington, A. Smeglin, N. Parks, J. Newton, and S. Rounds
Adenosine induces endothelial apoptosis by activating protein tyrosine phosphatase: a possible role of p38alpha
Am J Physiol Lung Cell Mol Physiol, October 1, 2000; 279(4): L733 - L742.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Cell Physiol.Home page
B. J. Gu, W. Y. Zhang, L. J. Bendall, I. P. Chessell, G. N. Buell, and J. S. Wiley
Expression of P2X7 purinoceptors on human lymphocytes and monocytes: evidence for nonfunctional P2X7 receptors
Am J Physiol Cell Physiol, October 1, 2000; 279(4): C1189 - C1197.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Cell Physiol.Home page
B. Morales, N. Barrera, P. Uribe, C. Mora, and M. Villalon
Functional cross talk after activation of P2 and P1 receptors in oviductal ciliated cells
Am J Physiol Cell Physiol, September 1, 2000; 279(3): C658 - C669.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Teixeira, E. Ferrary, and D. Butlen
UTP binding and phosphoinositidase C activation in ampulla from frog semicircular canal
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2000; 279(3): R803 - R812.
[Abstract] [Full Text] [PDF]


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J. Appl. Physiol.Home page
J. A. Felix, E. R. Dirksen, and M. L. Woodruff
Physiology of a Microgravity Environment: Selected Contribution: PKC activation inhibits Ca2+ signaling in tracheal epithelial cells kept in simulated microgravity
J Appl Physiol, August 1, 2000; 89(2): 855 - 864.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
C.-M. Yang, W.-B. Wu, S.-L. Pan, Y.-J. Tsai, C.-T. Chiu, and C.-C. Wang
P2Y2 receptor-stimulated phosphoinositide hydrolysis and Ca2+ mobilization in tracheal epithelial cells
Am J Physiol Lung Cell Mol Physiol, August 1, 2000; 279(2): L235 - L241.
[Abstract] [Full Text] [PDF]


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BloodHome page
O. K. Nihei, A. C. C. de Carvalho, W. Savino, and L. A. Alves
Pharmacologic properties of P2Z/P2X7 receptor characterized in murine dendritic cells: role on the induction of apoptosis
Blood, August 1, 2000; 96(3): 996 - 1005.
[Abstract] [Full Text] [PDF]


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J. Neurosci.Home page
J. S. H. Liu, G. R. John, A. Sikora, S. C. Lee, and C. F. Brosnan
Modulation of Interleukin-1beta and Tumor Necrosis Factor alpha Signaling by P2 Purinergic Receptors in Human Fetal Astrocytes
J. Neurosci., July 15, 2000; 20(14): 5292 - 5299.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Heart Circ. Physiol.Home page
V. Sauzeau, H. le Jeune, C. Cario-Toumaniantz, N. Vaillant, A.-P. Gadeau, C. Desgranges, E. Scalbert, P. Chardin, P. Pacaud, and G. Loirand
P2Y1, P2Y2, P2Y4, and P2Y6 receptors are coupled to Rho and Rho kinase activation in vascular myocytes
Am J Physiol Heart Circ Physiol, June 1, 2000; 278(6): H1751 - H1761.
[Abstract] [Full Text] [PDF]


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Physiol. Rev.Home page
J. C. Rekling, G. D. Funk, D. A. Bayliss, X.-W. Dong, and J. L. Feldman
Synaptic Control of Motoneuronal Excitability
Physiol Rev, April 1, 2000; 80(2): 767 - 852.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
D.-M. Zhao, H.-H. Xue, K. Chida, T. Suda, Y. Oki, M. Kanai, C. Uchida, A. Ichiyama, and H. Nakamura
Effect of erythromycin on ATP-induced intracellular calcium response in A549 cells
Am J Physiol Lung Cell Mol Physiol, April 1, 2000; 278(4): L726 - L736.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Gastrointest. Liver Physiol.Home page
K. D. Salter, J. G. Fitz, and R. M. Roman
Domain-specific purinergic signaling in polarized rat cholangiocytes
Am J Physiol Gastrointest Liver Physiol, March 1, 2000; 278(3): G492 - G500.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
J. Sevigny, S. C. Robson, E. Waelkens, E. Csizmadia, R. N. Smith, and R. Lemmens
Identification and Characterization of a Novel Hepatic Canalicular ATP Diphosphohydrolase
J. Biol. Chem., February 25, 2000; 275(8): 5640 - 5647.
[Abstract] [Full Text] [PDF]


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JNCI J Natl Cancer InstHome page
H. J. Agteresch, P. C. Dagnelie, A. van der Gaast, T. Stijnen, and J. H. P. Wilson
Randomized Clinical Trial of Adenosine 5'-Triphosphate in Patients With Advanced Non-Small-Cell Lung Cancer
J Natl Cancer Inst, February 16, 2000; 92(4): 321 - 328.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
K. Koziak, E. Kaczmarek, A. Kittel, J. Sevigny, J. K. Blusztajn, J. Schulte am Esch II, M. Imai, O. Guckelberger, C. Goepfert, I. Qawi, et al.
Palmitoylation Targets CD39/Endothelial ATP Diphosphohydrolase to Caveolae
J. Biol. Chem., January 21, 2000; 275(3): 2057 - 2062.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
J. S. Glavy, S. M. Wu, P. J. Wang, G. A. Orr, and A. W. Wolkoff
Down-regulation by Extracellular ATP of Rat Hepatocyte Organic Anion Transport Is Mediated by Serine Phosphorylation of Oatp1
J. Biol. Chem., January 14, 2000; 275(2): 1479 - 1484.
[Abstract] [Full Text] [PDF]


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J. Immunol.Home page
D. J. Kusner and J. Adams
ATP-Induced Killing of Virulent Mycobacterium tuberculosis Within Human Macrophages Requires Phospholipase D
J. Immunol., January 1, 2000; 164(1): 379 - 388.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
M. A. Balboa, J. Balsinde, C. A. Johnson, and E. A. Dennis
Regulation of Arachidonic Acid Mobilization in Lipopolysaccharide-activated P388D1 Macrophages by Adenosine Triphosphate
J. Biol. Chem., December 17, 1999; 274(51): 36764 - 36768.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Renal Physiol.Home page
J. van Baal, J. G. J. Hoenderop, M. Groenendijk, C. H. van Os, R. J. M. Bindels, and P. H. G. M. Willems
Hormone-stimulated Ca2+ transport in rabbit kidney: multiple sites of inhibition by exogenous ATP
Am J Physiol Renal Physiol, December 1, 1999; 277(6): F899 - F906.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
S. Rounds, L. L. Likar, E. O. Harrington, K. C. Kim, A. Smeglin, K. Heins, and N. Parks
Nucleotide-induced PMN adhesion to cultured epithelial cells: possible role of MUC1 mucin
Am J Physiol Lung Cell Mol Physiol, November 1, 1999; 277(5): L874 - L880.
[Abstract] [Full Text] [PDF]


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J. Pharmacol. Exp. Ther.Home page
K.-I. Hosoya, H. Ueda, K.-J. Kim, and V. H. L. Lee
Nucleotide Stimulation of Cl- Secretion in the Pigmented Rabbit Conjunctiva
J. Pharmacol. Exp. Ther., October 1, 1999; 291(1): 53 - 59.
[Abstract] [Full Text]


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Infect. Immun.Home page
O. Zaborina, N. Misra, J. Kostal, S. Kamath, V. Kapatral, M. E.-A. El-Idrissi, B. S. Prabhakar, and A. M. Chakrabarty
P2Z-Independent and P2Z Receptor-Mediated Macrophage Killing by Pseudomonas aeruginosa Isolated from Cystic Fibrosis Patients
Infect. Immun., October 1, 1999; 67(10): 5231 - 5242.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Cell Physiol.Home page
W. P. Schilling, W. G. Sinkins, and M. Estacion
Maitotoxin activates a nonselective cation channel and a P2Z/P2X7-like cytolytic pore in human skin fibroblasts
Am J Physiol Cell Physiol, October 1, 1999; 277(4): C755 - C765.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Cell Physiol.Home page
W. P. Schilling, T. Wasylyna, G. R. Dubyak, B. D. Humphreys, and W. G. Sinkins
Maitotoxin and P2Z/P2X7 purinergic receptor stimulation activate a common cytolytic pore
Am J Physiol Cell Physiol, October 1, 1999; 277(4): C766 - C776.
[Abstract] [Full Text] [PDF]


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Am. J. Physiol. Renal Physiol.Home page
D. E. McCoy, A. L. Taylor, B. A. Kudlow, K. Karlson, M. J. Slattery, L. M. Schwiebert, E. M. Schwiebert, and B. A. Stanton
Nucleotides regulate NaCl transport in mIMCD-K2 cells via P2X and P2Y purinergic receptors
Am J Physiol Renal Physiol, October 1, 1999; 277(4): F552 - F559.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
L. Homolya, W. C. Watt, E. R. Lazarowski, B. H. Koller, and R. C. Boucher
Nucleotide-regulated Calcium Signaling in Lung Fibroblasts and Epithelial Cells from Normal and P2Y2 Receptor (-/-) Mice
J. Biol. Chem., September 10, 1999; 274(37): 26454 - 26460.
[Abstract] [Full Text] [PDF]




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