Am J Physiol Cell Physiol AJP: Advances in Physiology Education
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Am J Physiol Cell Physiol 265: C497-C506, 1993;
0363-6143/93 $5.00
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AJP - Cell Physiology, Vol 265, Issue 2 C497-C506, Copyright © 1993 by American Physiological Society

ARTICLES

Computer modeling of the oxygen supply and demand of cells of the avian growth cartilage

J. C. Haselgrove, I. M. Shapiro and S. F. Silverton
Department of Biochemistry, School of Dental Medicine, University of Pennsylvania, Philadelphia 19104.

We have used computer modeling studies to investigate the oxygen supply to the prehypertrophic and hypertrophic regions of avian growth plate. We measured experimentally the characteristics of the oxygen consumption of chondrocytes at different oxygen tensions. The oxygen consumption decreases at low oxygen tensions. This relation between oxygen tension and oxygen consumption serves as a protective mechanism that prevents the cells in the prehypertrophic zone from becoming anoxic in the regions farthest from the blood vessels. The results of the calculations, when combined with redox measurements of the cells in the growth plate, indicate that the metabolism of the chondrocytes is not controlled simply by the available oxygen supply.


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P. Malladi, Y. Xu, M. Chiou, A. J. Giaccia, and M. T. Longaker
Effect of reduced oxygen tension on chondrogenesis and osteogenesis in adipose-derived mesenchymal cells
Am J Physiol Cell Physiol, April 1, 2006; 290(4): C1139 - C1146.
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