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Am J Physiol Cell Physiol 265: C375-C378, 1993;
0363-6143/93 $5.00
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AJP - Cell Physiology, Vol 265, Issue 2 C375-C378, Copyright © 1993 by American Physiological Society

ARTICLES

Perinatal enhancement of cardiac myofibrillar creatine kinase activity without change in enzyme Km

R. T. Dowell and M. C. Fu
Tobacco and Health Research Institute, University of Kentucky, Lexington 40546-0236.

Myofibrillar creatine kinase (CK) serves as one microcompartment of the phosphorylcreatine shuttle by providing ATP as substrate for adenosinetriphosphatase (ATPase). During perinatal heart development, augmentations of myofibrillar ATPase and CK occur in concert with increased contractile performance. The maximal reaction velocity (Vmax) for CK doubles during development in both intact native myofibril and enzyme extracted from myofibril. The absence of alterations in ADP and creatine phosphate substrate Michaelis constants (Km), isoenzyme composition, or total number of -SH groups suggests active site function (Vmax) is influenced indirectly via a subunit domain effect on enzyme conformation.




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