| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Cell Physiology, Vol 264, Issue 6 C1619-C1624, Copyright © 1993 by American Physiological Society
ARTICLES |
M. Fukunaga, N. Makita, L. J. Roberts 2nd, J. D. Morrow, K. Takahashi and K. F. Badr
Department of Medicine, Emory University, Atlanta, Georgia.
The isoprostanes are nonenzymatically generated prostanoids synthesized in vivo in humans and rats through reactions catalyzed by free oxygen radicals. 8-Epi-prostaglandin F2 alpha (8-epi-PGF2 alpha), an F2-isoprostane, is a potent smooth muscle constrictor. A thromboxane A2 (TxA2) receptor antagonist, SQ 29548, blocks renal vasoconstriction during 8-epi-PGF2 alpha administration in rats. With the use of cultured rat aortic smooth muscle cells, we found specific binding sites for [3H]SQ 29548 and for [125I]BOP, a TxA2 agonist. Both ligands were displaced from these binding sites by 8-epi-PGF2 alpha, although with significantly lesser potency than nonlabeled SQ 29548, I-BOP, or U-46619, a TxA2 agonist. In contrast, 8-epi-PGF2 alpha stimulated inositol 1,4,5-trisphosphate production and DNA synthesis in these cells with significantly greater potency than any TxA2 agonist, effects only partially inhibited by SQ 29548. In human TxA2 receptor cDNA-transfected cells, competition by 8-epi-PGF2 alpha for specific [3H]SQ 29548 binding was negligible. Thus 8-epi-PGF2 alpha probably exerts its biological actions in vascular smooth muscle through activation of receptor sites related to but distinct from TxA2 receptors. The existence of such binding sites suggests novel avenues for investigation into the biology of TxA2 and of free radical-mediated tissue injury.
This article has been cited by other articles:
|
|
 |
|
  W. J. Welch Effects of isoprostane on tubuloglomerular feedback: roles of TP receptors, NOS, and salt intake Am J Physiol Renal Physiol, April 1, 2005; 288(4): F757 - F762. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Catalli and L. J. Janssen Augmentation of bovine airway smooth muscle responsiveness to carbachol, KCl, and histamine by the isoprostane 8-iso-PGE2 Am J Physiol Lung Cell Mol Physiol, November 1, 2004; 287(5): L1035 - L1041. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. S. Gragasin, Y. Xu, I. A. Arenas, N. Kainth, and S. T. Davidge Estrogen Reduces Angiotensin II-Induced Nitric Oxide Synthase and NAD(P)H Oxidase Expression in Endothelial Cells Arterioscler. Thromb. Vasc. Biol., January 1, 2003; 23(1): 38 - 44. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Morrow and L. J. Roberts The Isoprostanes: Their Role as an Index of Oxidant Stress Status in Human Pulmonary Disease Am. J. Respir. Crit. Care Med., December 15, 2002; 166(12): S25 - 30. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. D. Krier, M. Rodriguez-Porcel, P. J. M. Best, J. C. Romero, A. Lerman, and L. O. Lerman Vascular responses in vivo to 8-epi PGF2alpha in normal and hypercholesterolemic pigs Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2002; 283(2): R303 - R308. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. P. Jankov, R. Belcastro, E. Ovcina, J. Lee, H. Massaeli, S. J. Lye, and A. K. Tanswell Thromboxane A2 Receptors Mediate Pulmonary Hypertension in 60% Oxygen-exposed Newborn Rats by a Cyclooxygenase-independent Mechanism Am. J. Respir. Crit. Care Med., July 15, 2002; 166(2): 208 - 214. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. J. Janssen and T. Tazzeo Involvement of TP and EP3 Receptors in Vasoconstrictor Responses to Isoprostanes in Pulmonary Vasculature J. Pharmacol. Exp. Ther., June 1, 2002; 301(3): 1060 - 1066. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Hou, L. J. Roberts II, D. F. Taber, J. D. Morrow, K. Kanai, F. Gobeil Jr., M. H. Beauchamp, S. G. Bernier, G. Lepage, D. R. Varma, et al. 2,3-Dinor-5,6-dihydro-15-F2t-isoprostane: a bioactive prostanoid metabolite Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2001; 281(2): R391 - R400. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Janssen Isoprostanes: an overview and putative roles in pulmonary pathophysiology Am J Physiol Lung Cell Mol Physiol, June 1, 2001; 280(6): L1067 - L1082. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Unmack, P. K. Rangachari, and E. Skadhauge Effects of Isoprostanes and Prostanoids on Porcine Small Intestine J. Pharmacol. Exp. Ther., April 13, 2001; 296(2): 434 - 441. [Abstract] [Full Text]
|
|
|
|
|
|
J. D. Imig Eicosanoid regulation of the renal vasculature Am J Physiol Renal Physiol, December 1, 2000; 279(6): F965 - F981. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. W. WALSH, J. E. VAUGHAN, Y. WANG, and L. J. ROBERTS II Placental isoprostane is significantly increased in preeclampsia FASEB J, July 1, 2000; 14(10): 1289 - 1296. [Abstract] [Full Text]
|
|
|
|
 |
|
 L. P. Audoly, B. Rocca, J.-E. Fabre, B. H. Koller, D. Thomas, A. L. Loeb, T. M. Coffman, and G. A. FitzGerald Cardiovascular Responses to the Isoprostanes iPF2{alpha}-III and iPE2-III Are Mediated via the Thromboxane A2 Receptor In Vivo Circulation, June 20, 2000; 101(24): 2833 - 2840. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. C. Romero and J. F. Reckelhoff Role of Angiotensin and Oxidative Stress in Essential Hypertension Hypertension, October 1, 1999; 34(4): 943 - 949. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. B. JOURDAN, T. W. EVANS, P. GOLDSTRAW, and J. A. MITCHELL Isoprostanes and PGE2 production in human isolated pulmonary artery smooth muscle cells: concomitant and differential release FASEB J, June 1, 1999; 13(9): 1025 - 1030. [Abstract] [Full Text]
|
|
|
|
 |
|
 R. Chinery, R. J. Coffey, R. Graves-Deal, S. C. Kirkland, S. C. Sanchez, W. E. Zackert, J. A. Oates, and J. D. Morrow Prostaglandin J2 and 15-Deoxy-{{Delta}}12,14-prostaglandin J2 Induce Proliferation of Cyclooxygenase-depleted Colorectal Cancer Cells Cancer Res., June 1, 1999; 59(11): 2739 - 2746. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. S. R. Baker, R. J. C. Hall, T. J. Evans, A. Pomerance, J. Maclouf, C. Creminon, M. H. Yacoub, and J. M. Polak Cyclooxygenase-2 Is Widely Expressed in Atherosclerotic Lesions Affecting Native and Transplanted Human Coronary Arteries and Colocalizes With Inducible Nitric Oxide Synthase and Nitrotyrosine Particularly in Macrophages Arterioscler. Thromb. Vasc. Biol., March 1, 1999; 19(3): 646 - 655. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. G. Schnackenberg and C. S. Wilcox Two-Week Administration of Tempol Attenuates Both Hypertension and Renal Excretion of 8-Iso Prostaglandin F2{alpha} Hypertension, January 1, 1999; 33(1): 424 - 428. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. P. Reilly, D. Pratico, N. Delanty, G. DiMinno, E. Tremoli, D. Rader, S. Kapoor, J. Rokach, J. Lawson, and G. A. FitzGerald Increased Formation of Distinct F2 Isoprostanes in Hypercholesterolemia Circulation, December 22, 1998; 98(25): 2822 - 2828. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. P. Moore, S. G. Holt, R. P. Patel, D. A. Svistunenko, W. Zackert, D. Goodier, Brandon. J. Reeder, M. Clozel, R. Anand, C. E. Cooper, et al. A Causative Role for Redox Cycling of Myoglobin and Its Inhibition by Alkalinization in the Pathogenesis and Treatment of Rhabdomyolysis-induced Renal Failure J. Biol. Chem., November 27, 1998; 273(48): 31731 - 31737. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Kunapuli, J. A. Lawson, J. A. Rokach, J. L. Meinkoth, and G. A. FitzGerald Prostaglandin F2alpha (PGF2alpha ) and the Isoprostane, 8,12-iso-Isoprostane F2alpha -III, Induce Cardiomyocyte Hypertrophy. DIFFERENTIAL ACTIVATION OF DOWNSTREAM SIGNALING PATHWAYS J. Biol. Chem., August 28, 1998; 273(35): 22442 - 22452. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Lahaie, P. Hardy, X. Hou, H. Hassessian, P. Asselin, P. Lachapelle, G. Almazan, D. R. Varma, J. D. Morrow, L. J. Roberts II, et al. A novel mechanism for vasoconstrictor action of 8-isoprostaglandin F2alpha on retinal vessels Am J Physiol Regulatory Integrative Comp Physiol, May 1, 1998; 274(5): R1406 - R1416. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Pratico, O. P. Barry, J. A. Lawson, M. Adiyaman, S.-W. Hwang, S. P. Khanapure, L. Iuliano, J. Rokach, and G. A. FitzGerald IPF2alpha -I: An index of lipid peroxidation in humans PNAS, March 31, 1998; 95(7): 3449 - 3454. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Patrono and G. A. FitzGerald Isoprostanes: Potential Markers of Oxidant Stress in Atherothrombotic Disease Arterioscler. Thromb. Vasc. Biol., November 1, 1997; 17(11): 2309 - 2315. [Abstract] [Full Text]
|
|
|
|
|
|
P. Kunapuli, J. A. Lawson, J. Rokach, and G. A. FitzGerald Functional Characterization of the Ocular Prostaglandin F2alpha (PGF2alpha ) Receptor. ACTIVATION BY THE ISOPROSTANE, 12-iso-PGF2alpha J. Biol. Chem., October 24, 1997; 272(43): 27147 - 27154. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Elmhurst, P.-A. Betti, and P. K. Rangachari Intestinal Effects of Isoprostanes: Evidence for the Involvement of Prostanoid EP and TP Receptors J. Pharmacol. Exp. Ther., September 1, 1997; 282(3): 1198 - 1205. [Abstract] [Full Text]
|
|
|
|
|
|
T. Klein, F. Reutter, H. Schweer, H. W. Seyberth, and R. M. Nüsing Generation of the Isoprostane 8-Epi-prostaglandin F2alpha In Vitro and In Vivo via the Cyclooxygenases J. Pharmacol. Exp. Ther., September 1, 1997; 282(3): 1658 - 1665. [Abstract] [Full Text]
|
|
|
|
|
|
B. T. Kinsella, D. J. O'Mahony, and G. A. Fitzgerald The Human Thromboxane A2 Receptor alpha Isoform (TPalpha ) Functionally Couples to the G Proteins Gq and G11 In Vivo and is Activated by the Isoprostane 8-epi Prostaglandin F2alpha J. Pharmacol. Exp. Ther., May 1, 1997; 281(2): 957 - 964. [Abstract] [Full Text]
|
|
|
|
 |
|
 S. W. Hoffman, S. Moore, and E. F. Ellis Isoprostanes: Free Radical–Generated Prostaglandins With Constrictor Effects on Cerebral Arterioles Stroke, April 1, 1997; 28(4): 844 - 849. [Abstract] [Full Text]
|
|
|
|
|
|
J. D. Morrow, J. A. Awad, A. Wu, W. E. Zackert, V. C. Daniel, and L. J. Roberts II Nonenzymatic Free Radical-catalyzed Generation of Thromboxane-like Compounds (Isothromboxanes) in Vivo J. Biol. Chem., September 20, 1996; 271(38): 23185 - 23190. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. J. Roberts II, K. P. Moore, W. E. Zackert, J. A. Oates, and J. D. Morrow Identification of the Major Urinary Metabolite of the F2-isoprostane 8-Iso-prostaglandin F2alpha in Humans J. Biol. Chem., August 23, 1996; 271(34): 20617 - 20620. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. P. Moore, V. Darley-Usmar, J. Morrow, and L. J. Roberts II Formation of F2-Isoprostanes During Oxidation of Human Low-Density Lipoprotein and Plasma by Peroxynitrite Circ. Res., August 1, 1995; 77(2): 335 - 341. [Abstract] [Full Text]
|
|
|
|
|
|
D. Pratico and G. A. FitzGerald Testosterone and Thromboxane : Of Muscles, Mice, and Men Circulation, June 1, 1995; 91(11): 2694 - 2698. [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
