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Am J Physiol Cell Physiol 264: C1395-C1400, 1993;
0363-6143/93 $5.00
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AJP - Cell Physiology, Vol 264, Issue 6 C1395-C1400, Copyright © 1993 by American Physiological Society

ARTICLES

Active oxygen species in the liver of rats submitted to chronic hypobaric hypoxia

L. E. Costa, S. Llesuy and A. Boveris
Instituto de Investigaciones Cardiologicas, Facultad de Medicina, Universidad de Buenos Aires, Argentina.

The spontaneous in situ liver chemiluminescence of female rats submitted to 4,400 m (simulated altitude) for 2 mo and of their corresponding controls at sea level was determined as an approach to the measurement of the intracellular steady-state concentrations of singlet oxygen and oxygen free radicals. Spontaneous liver chemiluminescence was decreased by approximately 40% in hypoxic rats, whereas CCl4-induced chemiluminescence was unchanged. Liver mitochondria isolated from hypoxic rats showed a 53% decreased rate of H2O2 production and an increased content of cytochrome b (36%), with normal content of cytochromes c1, c, and a-a3. Superoxide dismutase showed a 26% decrease in activity, whereas catalase and glutathione peroxidase activities were not significantly decreased by this extent of hypoxia. Cytochrome P-450 and glutathione contents were unchanged. There were no significant differences in the hydroperoxide-initiated chemiluminescence (an estimation of tissue chain-breaker antioxidants) of homogenates, mitochondria, and microsomes. Results suggest that in chronic hypoxia there is a lower rate of generation of active oxygen species in liver, leading to a decreased steady-state concentration of singlet oxygen.


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