Am J Physiol Cell Physiol Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Cell Physiol 264: C1180-C1189, 1993;
0363-6143/93 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Moore, R. L.
Right arrow Articles by Cheung, J. Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Moore, R. L.
Right arrow Articles by Cheung, J. Y.

AJP - Cell Physiology, Vol 264, Issue 5 C1180-C1189, Copyright © 1993 by American Physiological Society

ARTICLES

Chronic exercise alters contractility and morphology of isolated rat cardiac myocytes

R. L. Moore, T. I. Musch, R. V. Yelamarty, R. C. Scaduto Jr, A. M. Semanchick, M. Elensky and J. Y. Cheung
Department of Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.

Chronic exercise training elicits positive adaptations in cardiac contractile function and ventricular dimension. The potential contribution of single myocyte morphological and functional adaptations to these global responses to training was determined in this study. Left ventricular cardiac myocytes were isolated from the hearts of sedentary control (Sed) or exercise-trained (TR) rats. Training elicited an approximately 5% increase in resting myocyte length (Sed, 121.0 +/- 2.0 vs. TR, 126.7 +/- 2.0 microns; P < 0.05), whereas resting sarcomere length and midpoint cell width were unaffected. These data suggest that longitudinal myocyte growth contributes to the training-induced increase in end-diastolic dimension. Single myocytes (28 degrees C) were stimulated at 0.067 and 0.2 Hz and shortening dynamics assessed at extracellular Ca2+ concentrations ([Ca2+]o) of 0.6, 1.1, and 2.0 mM. In both groups, maximal extent of myocyte shortening (ESmax) increased as [Ca2+]o increased and decreased as contraction frequency increased. TR myocytes were more strongly influenced by the effects of [Ca2+]o and frequency. At 0.067 Hz and 2.0 mM, ESmax was greater in TR than in Sed myocytes. The magnitude of this difference decreased as [Ca2+]o was reduced. At 0.2 Hz, ESmax was similar in Sed and TR myocytes at 2.0 mM [Ca2+]o. As [Ca2+]o was reduced, ESmax decreased more rapidly in TR than in Sed myocytes; at 0.6 mM, ESmax was greater in Sed than in TR myocytes. Our data indicate that chronic exercise influences cardiac contractile function at the single myocyte level. This study also provides evidence in support of the hypothesis that chronic exercise influences myocyte Ca2+ influx and efflux pathways.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. A. Emter, S. A. McCune, G. C. Sparagna, M. J. Radin, and R. L. Moore
Low-intensity exercise training delays onset of decompensated heart failure in spontaneously hypertensive heart failure rats
Am J Physiol Heart Circ Physiol, November 1, 2005; 289(5): H2030 - H2038.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
F. Favret, K. K. Henderson, J.-P. Richalet, and N. C. Gonzalez
Effects of exercise training on acclimatization to hypoxia: systemic O2 transport during maximal exercise
J Appl Physiol, October 1, 2003; 95(4): 1531 - 1541.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
Y.-C. Ng, M. Nagarajan, K. N. Jew, L. C. Mace, and R. L. Moore
Exercise training differentially modifies age-associated alteration in expression of Na+-K+-ATPase subunit isoforms in rat skeletal muscles
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2003; 285(4): R733 - R740.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. M. Diffee and D. F. Nagle
Regional differences in effects of exercise training on contractile and biochemical properties of rat cardiac myocytes
J Appl Physiol, July 1, 2003; 95(1): 35 - 42.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. M. Diffee and E. Chung
Altered single cell force-velocity and power properties in exercise-trained rat myocardium
J Appl Physiol, May 1, 2003; 94(5): 1941 - 1948.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. M. Diffee and D. F. Nagle
Exercise training alters length dependence of contractile properties in rat myocardium
J Appl Physiol, March 1, 2003; 94(3): 1137 - 1144.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
G. M. Diffee, E. A. Seversen, T. D. Stein, and J. A. Johnson
Microarray expression analysis of effects of exercise training: increase in atrial MLC-1 in rat ventricles
Am J Physiol Heart Circ Physiol, March 1, 2003; 284(3): H830 - H837.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
O. J. Kemi, J. P. Loennechen, U. Wisloff, and O. Ellingsen
Intensity-controlled treadmill running in mice: cardiac and skeletal muscle hypertrophy
J Appl Physiol, October 1, 2002; 93(4): 1301 - 1309.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
X.-Q. Zhang, J. Song, L. L. Carl, W. Shi, A. Qureshi, Q. Tian, and J. Y. Cheung
Effects of sprint training on contractility and [Ca2+]i transients in adult rat myocytes
J Appl Physiol, October 1, 2002; 93(4): 1310 - 1317.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
A. Calderone, R. J. L. Murphy, J. Lavoie, F. Colombo, and L. Beliveau
TGF-{beta}1 and prepro-ANP mRNAs are differentially regulated in exercise-induced cardiac hypertrophy
J Appl Physiol, August 1, 2001; 91(2): 771 - 776.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
G. M. Diffee, E. A. Seversen, and M. M. Titus
Exercise training increases the Ca2+ sensitivity of tension in rat cardiac myocytes
J Appl Physiol, July 1, 2001; 91(1): 309 - 315.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. M. Palmer, J. M. Lynch, S. M. Snyder, and R. L. Moore
Renal hypertension prevents run training modification of cardiomyocyte diastolic Ca2+ regulation in male rats
J Appl Physiol, June 1, 2001; 90(6): 2063 - 2069.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. N. Jew, M. C. Olsson, E. A. Mokelke, B. M. Palmer, and R. L. Moore
Endurance training alters outward K+ current characteristics in rat cardiocytes
J Appl Physiol, April 1, 2001; 90(4): 1327 - 1333.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
U. Wisloff, J. Helgerud, O. J. Kemi, and O. Ellingsen
Intensity-controlled treadmill running in rats: {V}O2 max and cardiac hypertrophy
Am J Physiol Heart Circ Physiol, March 1, 2001; 280(3): H1301 - H1310.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L.-Q. Zhang, X.-Q. Zhang, T. I. Musch, R. L. Moore, and J. Y. Cheung
Sprint training restores normal contractility in postinfarction rat myocytes
J Appl Physiol, September 1, 2000; 89(3): 1099 - 1105.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
L.-Q. Zhang, X.-Q. Zhang, Y.-C. Ng, L. I. Rothblum, T. I. Musch, R. L. Moore, and J. Y. Cheung
Sprint training normalizes Ca2+ transients and SR function in postinfarction rat myocytes
J Appl Physiol, July 1, 2000; 89(1): 38 - 46.
[Abstract] [Full Text] [PDF]

Home page
 CirculationHome page
Y. Eto, K. Yonekura, M. Sonoda, N. Arai, M. Sata, S. Sugiura, K. Takenaka, A. Gualberto, M. L. Hixon, M. W. Wagner, et al.
Calcineurin Is Activated in Rat Hearts With Physiological Left Ventricular Hypertrophy Induced by Voluntary Exercise Training
Circulation, May 9, 2000; 101(18): 2134 - 2137.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
B. M. Palmer, M. C. Olsson, J. M. Lynch, L. C. Mace, S. M. Snyder, S. Valent, and R. L. Moore
Chronic run training suppresses alpha -adrenergic response of rat cardiomyocytes and isovolumic left ventricle
Am J Physiol Heart Circ Physiol, December 1, 1999; 277(6): H2136 - H2144.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
J. Delgado, A. Saborido, M. Moran, and A. Megias
Chronic and acute exercise do not alter Ca2+ regulatory systems and ectonucleotidase activities in rat heart
J Appl Physiol, July 1, 1999; 87(1): 152 - 160.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
X.-Q. Zhang, T. I. Musch, R. Zelis, and J. Y. Cheung
Effects of impaired Ca2+ homeostasis on contraction in postinfarction myocytes
J Appl Physiol, March 1, 1999; 86(3): 943 - 950.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. M. Palmer, J. M. Lynch, S. M. Snyder, and R. L. Moore
Effects of chronic run training on Na+-dependent Ca2+ efflux from rat left ventricular myocytes
J Appl Physiol, February 1, 1999; 86(2): 584 - 591.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
B. M. Palmer, A. M. Thayer, S. M. Snyder, and R. L. Moore
Shortening and [Ca2+] dynamics of left ventricular myocytes isolated from exercise-trained rats
J Appl Physiol, December 1, 1998; 85(6): 2159 - 2168.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
X.-Q. Zhang, Y.-C. Ng, T. I. Musch, R. L. Moore, R. Zelis, and J. Y. Cheung
Sprint training attenuates myocyte hypertrophy and improves Ca2+ homeostasis in postinfarction myocytes
J Appl Physiol, February 1, 1998; 84(2): 544 - 552.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. N. Jew and R. L. Moore
Exercise training alters an anoxia-induced, glibenclamide-sensitive current in rat ventricular cardiocytes
J Appl Physiol, April 1, 2002; 92(4): 1473 - 1479.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online