| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Cell Physiology, Vol 261, Issue 4 C555-C564, Copyright © 1991 by American Physiological Society
ARTICLES |
H. O'Brodovich
Department of Pediatrics, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada.
The lung is a complex organ whose intrauterine development depends on many factors, one of which is a continuous secretion of large volumes of Cl(-)-enriched fluid by the pulmonary epithelium. At birth this fluid must be cleared, and it is now known that this process depends in large part on active Na+ transport by the pulmonary epithelium. Only recently has it been possible to culture some of the different lung epithelial cells so that it is possible to investigate the role of individual epithelial cell types, their individual cellular transport mechanisms, and how these are affected by developmental lung maturity.
This article has been cited by other articles:
|
|
 |
|
  J. Lei, C. N. Mariash, M. Bhargava, E. V. Wattenberg, and D. H. Ingbar T3 increases Na-K-ATPase activity via a MAPK/ERK1/2-dependent pathway in rat adult alveolar epithelial cells Am J Physiol Lung Cell Mol Physiol, April 1, 2008; 294(4): L749 - L754. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lei, C. H. Wendt, D. Fan, C. N. Mariash, and D. H. Ingbar Developmental acquisition of T3-sensitive Na-K-ATPase stimulation by rat alveolar epithelial cells Am J Physiol Lung Cell Mol Physiol, January 1, 2007; 292(1): L6 - L14. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. J. Blaisdell, M. M. Morales, A. C. O. Andrade, P. Bamford, M. Wasicko, and P. Welling Inhibition of CLC-2 chloride channel expression interrupts expansion of fetal lung cysts Am J Physiol Lung Cell Mol Physiol, February 1, 2004; 286(2): L420 - L426. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. B. Mustafa, R. J. DiGeronimo, J. A. Petershack, J. L. Alcorn, and S. R. Seidner Postnatal glucocorticoids induce {alpha}-ENaC formation and regulate glucocorticoid receptors in the preterm rabbit lung Am J Physiol Lung Cell Mol Physiol, January 1, 2004; 286(1): L73 - L80. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Mairbaurl, J. Weymann, A. Mohrlein, E. R. Swenson, M. Maggiorini, J. S. R. Gibbs, and P. Bartsch Nasal Epithelium Potential Difference at High Altitude (4,559 m): Evidence for Secretion Am. J. Respir. Crit. Care Med., March 15, 2003; 167(6): 862 - 867. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. H. Thome, I. C. Davis, S. V. Nguyen, B. J. Shelton, and S. Matalon Modulation of sodium transport in fetal alveolar epithelial cells by oxygen and corticosterone Am J Physiol Lung Cell Mol Physiol, February 1, 2003; 284(2): L376 - L385. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Nakamura, J. B. Stokes, and P. B. McCray Jr. Endogenous and exogenous glucocorticoid regulation of ENaC mRNA expression in developing kidney and lung Am J Physiol Cell Physiol, September 1, 2002; 283(3): C762 - C772. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. O'Brodovich Pulmonary edema fluid movement within the lung Am J Physiol Lung Cell Mol Physiol, December 1, 2001; 281(6): L1324 - L1326. [Full Text] [PDF]
|
|
|
|
|
|
A. Dagenais, C. Denis, M.-F. Vives, S. Girouard, C. Masse, T. Nguyen, T. Yamagata, C. Grygorczyk, R. Kothary, and Y. Berthiaume Modulation of {alpha}-ENaC and {alpha}1-Na+-K+-ATPase by cAMP and dexamethasone in alveolar epithelial cells Am J Physiol Lung Cell Mol Physiol, July 1, 2001; 281(1): L217 - L230. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 U. Thome, L. Chen, P. Factor, V. Dumasius, B. Freeman, J. Iasha Sznajder, and S. Matalon Na,K-ATPase Gene Transfer Mitigates an Oxidant-Induced Decrease of Active Sodium Transport in Rat Fetal ATII Cells Am. J. Respir. Cell Mol. Biol., March 1, 2001; 24(3): 245 - 252. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Lazrak, A. Samanta, and S. Matalon Biophysical properties and molecular characterization of amiloride-sensitive sodium channels in A549 cells Am J Physiol Lung Cell Mol Physiol, April 1, 2000; 278(4): L848 - L857. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Gaillard, J. Hinnrasky, S. Coscoy, P. Hofman, M. A. Matthay, E. Puchelle, and P. Barbry Early expression of beta - and gamma -subunits of epithelial sodium channel during human airway development Am J Physiol Lung Cell Mol Physiol, January 1, 2000; 278(1): L177 - L184. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Niisato, Y. Ito, and Y. Marunaka cAMP stimulates Na+ transport in rat fetal pneumocyte: involvement of a PTK- but not a PKA-dependent pathway Am J Physiol Lung Cell Mol Physiol, October 1, 1999; 277(4): L727 - L736. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Chalaka, D. H. Ingbar, R. Sharma, Z. Zhau, and C. H. Wendt Na+-K+-ATPase gene regulation by glucocorticoids in a fetal lung epithelial cell line Am J Physiol Lung Cell Mol Physiol, July 1, 1999; 277(1): L197 - L203. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Jain, X.-J. Chen, B. Malik, O. Al-Khalili, and D. C. Eaton Antisense oligonucleotides against the alpha -subunit of ENaC decrease lung epithelial cation-channel activity Am J Physiol Lung Cell Mol Physiol, June 1, 1999; 276(6): L1046 - L1051. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Jaffé, A Bush, D M Geddes, and E W F W Alton Prospects for gene therapy in cystic fibrosis Arch. Dis. Child., March 1, 1999; 80(3): 286 - 289. [Full Text]
|
|
|
|
|
|
X. Jiang, D. H. Ingbar, and S. M. O'Grady Adrenergic stimulation of Na+ transport across alveolar epithelial cells involves activation of apical Cl- channels Am J Physiol Cell Physiol, December 1, 1998; 275(6): C1610 - C1620. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. G. Nielsen, M. D. Duvall, M. S. Baird, and S. Matalon cAMP activation of chloride and fluid secretion across the rabbit alveolar epithelium Am J Physiol Lung Cell Mol Physiol, December 1, 1998; 275(6): L1127 - L1133. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. K. Ruddy, J. M. Drazen, O. M. Pitkanen, B. Rafii, H. M. O'Brodovich, and H. W. Harris Modulation of aquaporin 4 and the amiloride-inhibitable sodium channel in perinatal rat lung epithelial cells Am J Physiol Lung Cell Mol Physiol, June 1, 1998; 274(6): L1066 - L1072. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tanaka, N. Inase, K. Fushimi, K. Ishibashi, M. Ichioka, S. Sasaki, and F. Marumo Induction of aquaporin 3 by corticosteroid in a human airway epithelial cell line Am J Physiol Lung Cell Mol Physiol, November 1, 1997; 273(5): L1090 - L1095. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Mairbaurl, R. Wodopia, S. Eckes, S. Schulz, and P. Bartsch Impairment of cation transport in A549 cells and rat alveolar epithelial cells by hypoxia Am J Physiol Lung Cell Mol Physiol, October 1, 1997; 273(4): L797 - L806. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Collett, S. J. Ramminger, R. E. Olver, and S. M. Wilson Alveolar Epithelial Ion and Fluid Transport: beta -Adrenoceptor-mediated control of apical membrane conductive properties in fetal distal lung epithelia Am J Physiol Lung Cell Mol Physiol, April 1, 2002; 282(4): L621 - L630. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Mairbaurl, K. Mayer, K.-J. Kim, Z. Borok, P. Bartsch, and E. D. Crandall Alveolar Epithelial Ion and Fluid Transport: Hypoxia decreases active Na transport across primary rat alveolar epithelial cell monolayers Am J Physiol Lung Cell Mol Physiol, April 1, 2002; 282(4): L659 - L665. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Lazrak, U. Thome, C. Myles, J. Ware, L. Chen, C. J. Venglarik, and S. Matalon Alveolar Epithelial Ion and Fluid Transport: cAMP regulation of Cl- and HCO3- secretion across rat fetal distal lung epithelial cells Am J Physiol Lung Cell Mol Physiol, April 1, 2002; 282(4): L650 - L658. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
