Am J Physiol Cell Physiol Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Cell Physiol 261: C259-C270, 1991;
0363-6143/91 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mayne, C. N.
Right arrow Articles by Salmons, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mayne, C. N.
Right arrow Articles by Salmons, S.

AJP - Cell Physiology, Vol 261, Issue 2 C259-C270, Copyright © 1991 by American Physiological Society

ARTICLES

Correlates of fatigue resistance in canine skeletal muscle stimulated electrically for up to one year

C. N. Mayne, W. A. Anderson, R. L. Hammond, B. R. Eisenberg, L. W. Stephenson and S. Salmons
Department of Human Anatomy and Cell Biology, University of Liverpool, United Kingdom.

In response to patterns of chronic electrical stimulation that increase its overall level of use, mammalian skeletal muscle becomes highly resistant to fatigue. The metabolic basis for this adaptation is well documented in the rabbit, but up to now it has not been possible to identify analogous changes in the dog. In this study, canine latissimus dorsi muscles were stimulated in situ for 2, 6 and 12 mo. Marked increases in fatigue resistance were consistently demonstrated. Citrate synthase and succinic dehydrogenase, conventionally used as markers of oxidative metabolism, did not increase in activity, but enzymes involved in major pathways supplying substrates to the tricarboxylic acid cycle increased up to threefold. Stimulation elevated the volume fraction of mitochondria 1.5-fold and that of lipid droplets 4.5-fold. After 6 mo of stimulation, mean fiber diameter had decreased by 30% and the area occupied by nonmuscle tissue had increased by 11%; these changes showed no further progression at 12 mo. Thus stimulated muscle becomes stably adapted to an increase in use, but the metabolic strategies for achieving increased fatigue resistance vary between species.


This article has been cited by other articles:


Home page
 J. Appl. Physiol.Home page
A. R. Weston, O. Karamizrak, A. Smith, T. D. Noakes, and K. H. Myburgh
African runners exhibit greater fatigue resistance, lower lactate accumulation, and higher oxidative enzyme activity
J Appl Physiol, March 1, 1999; 86(3): 915 - 923.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. T. George, S. A. Binder-Macleod, T. N. Delosso, and W. P. Santamore
Variable-frequency train stimulation of canine latissimus dorsi muscle during shortening contractions
J Appl Physiol, September 1, 1997; 83(3): 994 - 1001.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online