Am J Physiol Cell Physiol Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Cell Physiol 260: C1212-C1216, 1991;
0363-6143/91 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nicoll, D. A.
Right arrow Articles by Philipson, K. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nicoll, D. A.
Right arrow Articles by Philipson, K. D.

AJP - Cell Physiology, Vol 260, Issue 6 C1212-C1216, Copyright © 1991 by American Physiological Society

ARTICLES

Na(+)-Ca2+ exchangers from rod outer segments and cardiac sarcolemma: comparison of properties

D. A. Nicoll, B. R. Barrios and K. D. Philipson
Department of Medicine, University of California, School of Medicine, Los Angeles 90024-1760.

The properties of the Na(+)-Ca2+ exchangers from cardiac sarcolemma (SL) and rod outer segments (ROS) were studied in parallel by measuring the Na+ gradient-dependent Ca2+ uptake into SL or ROS vesicles. The ROS exchanger, but not the SL exchanger, has a striking specific dependence on K+. The ROS exchanger is stimulated by K+ with an apparent concentration at half-maximum of 1 mM. The addition of valinomycin, to produce an inside-positive membrane potential, stimulates the SL exchanger 1.8-fold and the ROS exchanger 1.2-fold. The Michaelis constant for half-maximal transport rate for Ca2+ and the maximal transport rate for the exchangers, in the absence of valinomycin, are estimated to be 20 microM and 8 nmol.mg-1.2.2 s-1 in SL and 5 microM and 1 nmol.mg-1.2.2 s-1 in ROS. Both exchangers are modulated by the same regulatory influences. For example, both are stimulated by proteases, phospholipase D, and intravesicular Ca2+.


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
M. P. Blaustein and W. J. Lederer
Sodium/Calcium Exchange: Its Physiological Implications
Physiol Rev, July 1, 1999; 79(3): 763 - 854.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
L. D. Nelson, M. T. Unlap, J. L. Lewis, and P. D. Bell
Renal arteriolar Na+/Ca2+ exchange in salt-sensitive hypertension
Am J Physiol Renal Physiol, April 1, 1999; 276(4): F567 - F573.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
P. J. Bauer, H. Schauf, A. Schwarzer, and J. E. Brown
Direct evidence of Na+/Ca2+ exchange in squid rhabdomeric membranes
Am J Physiol Cell Physiol, March 1, 1999; 276(3): C558 - C565.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
T. S. Y. Kim, D. M. Reid, and R. S. Molday
Structure-Function Relationships and Localization of the Na/Ca-K Exchanger in Rod Photoreceptors
J. Biol. Chem., June 26, 1998; 273(26): 16561 - 16567.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online