Am J Physiol Cell Physiol AJP: Regulatory, Integrative and Comparative Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Cell Physiol 260: C805-C812, 1991;
0363-6143/91 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Adams, G. R.
Right arrow Articles by Meyer, R. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Adams, G. R.
Right arrow Articles by Meyer, R. A.

AJP - Cell Physiology, Vol 260, Issue 4 C805-C812, Copyright © 1991 by American Physiological Society

ARTICLES

Hypercapnic acidosis and increased H2PO4- concentration do not decrease force in cat skeletal muscle

G. R. Adams, M. J. Fisher and R. A. Meyer
Department of Physiology, Michigan State University, East Lansing 48824.

Peak tetanic tension was measured during acidosis resulting from either hypercapnia or repetitive tetanic stimulation in isolated, arterially perfused cat biceps brachii (predominantly fast twitch) or soleus (slow twitch) muscles. Phosphocreatine (PCr), Pi, intracellular pH (pHi), and extracellular pH (pHo) were monitored by 31P-nuclear magnetic resonance spectroscopy. During repetitive stimulation under normocapnic conditions (5% CO2, pHo 7.4) Pi increased, pHi decreased from 7.1 to 6.3, and there were significant correlations between both pHi and calculated [H2PO4-] vs. peak tetanic force in both muscle types. However, hypercapnic perfusion (70% CO2, pHo, 6.7, pHi 6.4-6.5) had no effect on peak tetanic force, and there was no significant correlation between pHi or [H2PO4-] during hypercapnia in either muscle. The results indicate that decreased peak tetanic force during repetitive stimulation is not directly due to changes in pHi or diprotonated phosphate.


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
D. G. Allen, G. D. Lamb, and H. Westerblad
Skeletal Muscle Fatigue: Cellular Mechanisms
Physiol Rev, January 1, 2008; 88(1): 287 - 332.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
E. P. Debold, H. Dave, and R. H. Fitts
Fiber type and temperature dependence of inorganic phosphate: implications for fatigue
Am J Physiol Cell Physiol, September 1, 2004; 287(3): C673 - C681.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
W. G. Aschenbach, G. L. Brower, R. J. Talmadge, J. L. Dobson, and L. B. Gladden
Effect of a myocardial volume overload on lactate transport in skeletal muscle sarcolemmal vesicles
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2001; 281(1): R176 - R186.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
J. A. L. Jeneson, H. V. Westerhoff, and M. J. Kushmerick
A metabolic control analysis of kinetic controls in ATP free energy metabolism in contracting skeletal muscle
Am J Physiol Cell Physiol, September 1, 2000; 279(3): C813 - C832.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
M. Tonkonogi and K. Sahlin
Actively phosphorylating mitochondria are more resistant to lactic acidosis than inactive mitochondria
Am J Physiol Cell Physiol, August 1, 1999; 277(2): C288 - C293.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
K. H. Myburgh and R. Cooke
Response of compressed skinned skeletal muscle fibers to conditions that simulate fatigue
J Appl Physiol, April 1, 1997; 82(4): 1297 - 1304.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online