Am J Physiol Cell Physiol AJP: Lung Cellular and Molecular Physiology
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Am J Physiol Cell Physiol 257: C1038-C1041, 1989;
0363-6143/89 $5.00
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AJP - Cell Physiology, Vol 257, Issue 5 C1038-C1041, Copyright © 1989 by American Physiological Society

ARTICLES

Role of Mg in the activation of Na-H exchange in dog red cells

J. C. Parker, H. J. Gitelman and T. J. McManus
Department of Medicine, University of North Carolina, Chapel Hill 27599.

Depleting dog red cells of Mg prevents activation of Na-H exchange by cell shrinkage but has no effect on activation by acidification of the cytosol. Replacing cell Mg restores the activation of Na-H exchange by cell shrinking. We conclude that Mg is required, not for the transport process per se, but for the transduction of the volume stimulus.


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[Abstract] [Full Text] [PDF]


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