AJP - Cell Physiology, Vol 257, Issue 4 C775-C780, Copyright © 1989 by American Physiological Society
Cardiac antisecretory peptide inhibits intestinal chloride secretion
S. M. O'Grady and P. J. Wolters
Department of Veterinary Biology, University of Minnesota, St. Paul 55108.
A heat-stable low-molecular-weight peptide isolated from porcine heart
inhibited vasoactive intestinal polypeptide and ionomycin (a Ca ionophore)
-stimulated Cl secretion across the rat ileum. The antisecretory effects of
this peptide were resistant to the neuronal conduction blocker
tetrodotoxin, suggesting that submucosal nerves were not involved in
mediating its effects on Cl transport. Activity was found in extracts of
the right and left atria and in the ventricles of the heart. The
antisecretory effect was not mimicked by atrial natriuretic factor, brain
natriuretic peptide, or by putative antisecretory factors (neuropeptide Y,
somatostatin, enkephalin, and norepinephrine), suggesting that cardiac
antisecretory peptide is a unique regulatory factor that may regulate Cl
transport in the intestinal mucosa and other epithelia.
