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Am J Physiol Cell Physiol 257: C759-C765, 1989;
0363-6143/89 $5.00
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AJP - Cell Physiology, Vol 257, Issue 4 C759-C765, Copyright © 1989 by American Physiological Society

ARTICLES

Malignant hyperthermia: slow sodium current in cultured human muscle cells

S. J. Wieland, J. E. Fletcher, H. Rosenberg and Q. H. Gong
Department of Anatomy, Hahnemann University, Philadelphia, Pennsylvania 19102.

Voltage-activated ion currents were measured in cultured skeletal muscle myoballs. Cultures were generated from biopsies from patients referred for diagnosis of susceptibility to malignant hyperthermia (MH); diagnosis of susceptibility (MH+) or nonsusceptibility (MH-) was made on the basis of in vitro halothane-induced contracture of a separate piece of biopsy. Measurements of ion currents were made at room temperature in the absence of anesthetic agents, using tight-seal whole-cell recording. Fast transient Na+ currents and delayed outward K+ currents were similar in magnitude and kinetics in cells from MH+ and MH- patients. An additional slowly inactivating inward current component was commonly observed in cells from MH+ patients. This current was blockable by tetrodotoxin and was carried by Na+ but not by Ba2+. The component was less frequently observed and was of a lower magnitude in cells from MH- patients. The increased magnitude of the slow inward current observed in cultured muscle cells from MH+ patients may be a manifestation of the lesion that causes MH.


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