Am J Physiol Cell Physiol Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Cell Physiol 257: C129-C140, 1989;
0363-6143/89 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Krouse, M. E.
Right arrow Articles by Wine, J. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Krouse, M. E.
Right arrow Articles by Wine, J. J.

AJP - Cell Physiology, Vol 257, Issue 1 C129-C140, Copyright © 1989 by American Physiological Society

ARTICLES

Ion channels in normal human and cystic fibrosis sweat gland cells

M. E. Krouse, G. Hagiwara, J. Chen, N. J. Lewiston and J. J. Wine
Cystic Fibrosis Research Laboratory, Stanford University, California.

Single-channel patch-clamp techniques were used to study the population of apical membrane ion channels in cultured sweat gland secretory cells from normal and cystic fibrosis subjects. Four types of anion channels and two types of cation channels were found. At physiological voltages, anion channels had chord conductances of 10, 18, 24, and greater than 200 pS. All had linear current-voltage relations except the 24 pS channel, which showed outward rectification. Cation channels had chord conductances of 5 and 18 pS, were linear, and were nonselective for a variety of cations. Channel types and proportions were equivalent in control, cystic fibrosis, and cystic fibrosis heterozygote cells. Beyond showing that the distribution of channel types remains unchanged in cystic fibrosis cells, the data provide a basis for comparison with cells cultured under different conditions, with other cell types, and with native tissues.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Cell Physiol.Home page
Y. Li, S. T. Halm, and D. R. Halm
Secretory activation of basolateral membrane Cl- channels in guinea pig distal colonic crypts
Am J Physiol Cell Physiol, April 1, 2003; 284(4): C918 - C933.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
J. M. McGill, M. S. Yen, O. W. Cummings, G. Alpini, G. LeSage, K. E. Pollok, B. Miller, S. K. Engle, and A. P. Stansfield
Interleukin-5 inhibition of biliary cell chloride currents and bile flow
Am J Physiol Gastrointest Liver Physiol, April 1, 2001; 280(4): G738 - G745.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online