AJP - Cell Physiology, Vol 256, Issue 6 C1262-C1266, Copyright © 1989 by American Physiological Society

ARTICLES

Muscle transplantation between young and old rats: age of host determines recovery

B. M. Carlson and J. A. Faulkner
Department of Anatomy, University of Michigan, Ann Arbor 48109.

As compared with age-matched controls, extensor digitorum longus (EDL) muscles autografted in young rats regenerated significantly greater mass (1.8 times) and developed greater maximum contractile force (2.6 times) than EDL muscles autografted in old rats. A cross-age transplantation study showed that the mass and maximum force of old muscles grafted into young hosts were not significantly different from those of young muscles grafted into the same young hosts. Conversely, young muscle grafted into old hosts regenerated no better than old muscles grafted into the same old hosts. We conclude 1) that chronological age alone is not a factor that limits the intrinsic ability of a muscle to regenerate and 2) that the poor regeneration of muscles in old animals is a function of the environment for regeneration provided by the old host.

This article has been cited by other articles:

				D. W. Hammers, E. K. Merritt, W. Matheny, M. L. Adamo, T. J. Walters, J. S. Estep, and R. P. Farrar Functional deficits and insulin-like growth factor-I gene expression following tourniquet-induced injury of skeletal muscle in young and old rats J Appl Physiol, October 1, 2008; 105(4): 1274 - 1281. [Abstract] [Full Text] [PDF]

				J. K. Petrella, J.-s. Kim, D. L. Mayhew, J. M. Cross, and M. M. Bamman Potent myofiber hypertrophy during resistance training in humans is associated with satellite cell-mediated myonuclear addition: a cluster analysis J Appl Physiol, June 1, 2008; 104(6): 1736 - 1742. [Abstract] [Full Text] [PDF]

				J. K. Petrella, J.-s. Kim, J. M. Cross, D. J. Kosek, and M. M. Bamman Efficacy of myonuclear addition may explain differential myofiber growth among resistance-trained young and older men and women Am J Physiol Endocrinol Metab, November 1, 2006; 291(5): E937 - E946. [Abstract] [Full Text] [PDF]

				X. Shi and D. J. Garry Muscle stem cells in development, regeneration, and disease. Genes & Dev., July 1, 2006; 20(13): 1692 - 1708. [Abstract] [Full Text] [PDF]

				E. P. Rader and J. A. Faulkner Recovery from contraction-induced injury is impaired in weight-bearing muscles of old male mice J Appl Physiol, February 1, 2006; 100(2): 656 - 661. [Abstract] [Full Text] [PDF]

				J.-s. Kim, D. J. Kosek, J. K. Petrella, J. M. Cross, and M. M. Bamman Resting and load-induced levels of myogenic gene transcripts differ between older adults with demonstrable sarcopenia and young men and women J Appl Physiol, December 1, 2005; 99(6): 2149 - 2158. [Abstract] [Full Text] [PDF]

				T. A. Hornberger, R. D. Mateja, E. R. Chin, J. L. Andrews, and K. A. Esser Aging does not alter the mechanosensitivity of the p38, p70S6k, and JNK2 signaling pathways in skeletal muscle J Appl Physiol, April 1, 2005; 98(4): 1562 - 1566. [Abstract] [Full Text] [PDF]

				S. B. P. CHARGE and M. A. RUDNICKI Cellular and Molecular Regulation of Muscle Regeneration Physiol Rev, January 1, 2004; 84(1): 209 - 238. [Abstract] [Full Text] [PDF]

				S. B. P. Charge, A. S. Brack, and S. M. Hughes Aging-related satellite cell differentiation defect occurs prematurely after Ski-induced muscle hypertrophy Am J Physiol Cell Physiol, October 1, 2002; 283(4): C1228 - C1241. [Abstract] [Full Text] [PDF]

				J. A. Carson, W. J. Lee, J. McClung, and G. A. Hand Steroid receptor concentration in aged rat hindlimb muscle: effect of anabolic steroid administration J Appl Physiol, July 1, 2002; 93(1): 242 - 250. [Abstract] [Full Text] [PDF]

				C. T. Putman, K. R. Sultan, T. Wassmer, J. A. Bamford, D. Skorjanc, and D. Pette Fiber-Type Transitions and Satellite Cell Activation in Low-Frequency-Stimulated Muscles of Young and Aging Rats J. Gerontol. A Biol. Sci. Med. Sci., December 1, 2001; 56(12): B510 - 519. [Abstract] [Full Text] [PDF]

				P. S. Cederna, H. Asato, X. Gu, J. van der Meulen, W. M. Kuzon Jr., B. M. Carlson, and J. A. Faulkner Motor Unit Properties of Nerve-Intact Extensor Digitorum Longus Muscle Grafts In Young and Old Rats J. Gerontol. A Biol. Sci. Med. Sci., June 1, 2001; 56(6): B254 - B258. [Abstract] [Full Text] [PDF]

				B. M. Carlson, E. I. Dedkov, A. B. Borisov, and J. A. Faulkner Skeletal Muscle Regeneration in Very Old Rats J. Gerontol. A Biol. Sci. Med. Sci., April 1, 2001; 56(5): 224B - 233. [Abstract] [Full Text]

				D. R. Marsh, D. S. Criswell, J. A. Carson, and F. W. Booth Myogenic regulatory factors during regeneration of skeletal muscle in young, adult, and old rats J Appl Physiol, October 1, 1997; 83(4): 1270 - 1275. [Abstract] [Full Text] [PDF]