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Am J Physiol Cell Physiol 256: C683-C687, 1989;
0363-6143/89 $5.00
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AJP - Cell Physiology, Vol 256, Issue 3 C683-C687, Copyright © 1989 by American Physiological Society

ARTICLES

Two distinct mechanisms are responsible for single K channel block by internal tetraethylammonium ions

D. Yamamoto and N. Suzuki
Laboratory of Neurophysiology, Mitsubishi-Kasei Institute of Life Sciences, Tokyo, Japan.

Tetraethylammonium (TEA) ions blocked the unitary currents through the delayed rectifier potassium channels of Drosophila neurons from the cytoplasmic side of inside-out membrane patches by two distinct mechanisms. First, TEA attenuated the single-channel conductance, probably by producing very rapid block-unblock reactions at the inner mouth of the potassium pore. Second, TEA markedly enhanced the slow inactivation, making the incidence of channel openings highly nonrandom; blank traces with no channel openings during repetitive depolarizations showed a significant tendency to be clustered in the presence of TEA. This second action accounts for almost half of the reduction of average current produced by 10 mM internal TEA.




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