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Am J Physiol Cell Physiol 256: C329-C335, 1989;
0363-6143/89 $5.00
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AJP - Cell Physiology, Vol 256, Issue 2 C329-C335, Copyright © 1989 by American Physiological Society

ARTICLES

A human airway smooth muscle cell line that retains physiological responsiveness

R. A. Panettieri, R. K. Murray, L. R. DePalo, P. A. Yadvish and M. I. Kotlikoff
Department of Medicine, University of Pennsylvania, Philadelphia 19104-6046.

We report the development of a nontransformed line of human airway smooth muscle cells retaining smooth muscle-specific contractile protein expression and physiological responsiveness to agonists implicated in inflammatory airway diseases. Specific responses to histamine, leukotrienes, bradykinin, platelet-activating factor, substance P, and thromboxane analogues are demonstrated as well as functional coupling to beta-adrenergic receptors. The cell line was characterized using indirect immunofluorescence, as well as electrophoretic separation and immunoblot analysis of smooth muscle-specific actin. Functional responses were assessed by measurements of cytosolic calcium and stimulation of adenosine 3',5'-cyclic monophosphate production. The cells retain their responsiveness over many population doublings and should be a useful model to examine specific receptor-effector mechanisms, as well as the effects of neurohumoral agents on the regulation of airway smooth muscle growth and differentiation.


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Am J Physiol Lung Cell Mol Physiol, July 1, 1999; 277(1): L22 - L29.
[Abstract] [Full Text] [PDF]

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 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
V. P. Krymskaya, R. B. Penn, M. J. Orsini, P. H. Scott, R. J. Plevin, T. R. Walker, A. J. Eszterhas, Y. Amrani, E. R. Chilvers, and R. A. Panettieri Jr.
Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation
Am J Physiol Lung Cell Mol Physiol, July 1, 1999; 277(1): L65 - L78.
[Abstract]