Am J Physiol Cell Physiol Journal of Applied Physiology
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Am J Physiol Cell Physiol 255: C543-C551, 1988;
0363-6143/88 $5.00
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AJP - Cell Physiology, Vol 255, Issue 4 C543-C551, Copyright © 1988 by American Physiological Society

ARTICLES

Chronic stimulation of mammalian muscle: changes in metabolite concentrations in individual fibers

J. Henriksson, S. Salmons, M. Y. Chi, C. S. Hintz and O. H. Lowry
Department of Physiology III, Karolinska Institutet, Stockholm, Sweden.

Single fibers were analyzed from rabbit fast-twitch tibialis anterior muscles freeze-clamped during continuous stimulation at 10 Hz for up to 8 wk. ATP declined after 1 wk to a stable level approximately 30% below controls. Phosphocreatine decreased earlier and to a greater extent (approximately 50%). Glycogen varied considerably among stimulated fibers and decreased on average approximately 75% by 8 wk. Glucose, lactate, citrate, and malate had changed little in the first 30 h and then increased four-, two-, four-, and sevenfold, respectively, over the next 5 wk. Glucose 6-phosphate showed the most unexpected behavior: with an overall upward trend, it descended to extremely low values (10% of control) after approximately 1 wk of stimulation. As long as high- and low-oxidative fibers were present, the former showed slightly higher levels of ATP, lactate, and malate; other metabolites did not differ in a consistent way. These unexpected observations, which differ strikingly from data for acute stimulation, shed light on adaptations that enable a chronically stimulated muscle to sustain a continuous high level of ATP utilization.


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