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Am J Physiol Cell Physiol 255: C377-C384, 1988;
0363-6143/88 $5.00
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AJP - Cell Physiology, Vol 255, Issue 3 C377-C384, Copyright © 1988 by American Physiological Society

ARTICLES

Intracellular sodium flux and high-energy phosphorus metabolites in ischemic skeletal muscle

H. Blum, M. D. Schnall, B. Chance and G. P. Buzby
Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia.

We have employed concurrent 31P- and 23Na-nuclear magnetic resonance (NMR) spectroscopy in conjunction with the paramagnetic shift reagents dysprosium-chelated tripolyphosphate and triethylenetetramine-hexa-acetic acid to observe the intracellular sodium and phosphorus signals in rat leg muscle. With induced ischemia in the leg, we find slowly falling phosphorylation potential. At a critical value of, associated with energetic failure of the Na+-K+ antiport, the intracellular sodium signal begins to increase. We find the following critical values: log, 3.12 +/- 0.32; pH, 6.86 +/- 0.13; Na+ influx with and without ouabain, 5.1 +/- 4.3 and 4.0 +/- 1.3 mol.l-1.h-1, respectively.


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