Am J Physiol Cell Physiol Track the topics, authors and articles important to you
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Cell Physiol 253: C45-C51, 1987;
0363-6143/87 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brommundt, G.
Right arrow Articles by Kavaler, F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brommundt, G.
Right arrow Articles by Kavaler, F.

AJP - Cell Physiology, Vol 253, Issue 1 C45-C51, Copyright © 1987 by American Physiological Society

ARTICLES

La3+, Mn2+, and Ni2+ effects on Ca2+ pump and on Na+-Ca2+ exchange in bullfrog ventricle

G. Brommundt and F. Kavaler

45Ca washout from ventricles of the bullfrog was followed through an automated technique previously described. Lanthanum decreased the fractional rate of loss of 45Ca (by 67% at the saturating concentration, 1 mM, for this effect of the trivalent cation). In contrast, both manganous and nickel ions decreased the fractional rate of loss of 45Ca in 21 of the 30 ventricles studied. In the remainder of the experiments these ions increased this rate. This augmentation of the rate of 45Ca efflux by manganese and nickel could be converted consistently to an inhibition by experimental maneuvers known to increase the intracellular concentration of sodium-potassium-free washout solution, dihydroouabain. These results are consistent with the hypothesis that manganese and nickel increase 45Ca efflux through a process of sarcolemmal manganese-calcium (or nickel-calcium) exchange, operating through the sodium-calcium exchanger. Support for this interpretation was obtained in the further observation that the rate of loss of radioactive nickel from 63Ni-loaded ventricles was monotonically related to the extracellular concentration of calcium. Thus the augmenting effect of the divalent cations on 45Ca efflux appears to be mediated by the sodium-calcium exchanger. That the inhibitory effect arises from an action of the cations on the ATP-dependent component of 45Ca efflux is indicated by the fact that it disappears after vigorous ATP depletion in the presence of cyanide and 2-deoxy-D-glucose.


This article has been cited by other articles:


Home page
 J. Physiol.Home page
S. Antolin and H. R. Matthews
The effect of external sodium concentration on sodium-calcium exchange in frog olfactory receptor cells
J. Physiol., June 1, 2007; 581(2): 495 - 503.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. P. Blaustein and W. J. Lederer
Sodium/Calcium Exchange: Its Physiological Implications
Physiol Rev, July 1, 1999; 79(3): 763 - 854.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
M. Egger, A. Ruknudin, E. Niggli, W. J. Lederer, and D. H. Schulze
Ni2+ transport by the human Na+/Ca2+ exchanger expressed in Sf 9 cells
Am J Physiol Cell Physiol, May 1, 1999; 276(5): C1184 - C1192.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online