Am J Physiol Cell Physiol AJP citation statistics
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Cell Physiol 252: C640-C649, 1987;
0363-6143/87 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Polla, B. S.
Right arrow Articles by Krane, S. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Polla, B. S.
Right arrow Articles by Krane, S. M.

AJP - Cell Physiology, Vol 252, Issue 6 C640-C649, Copyright © 1987 by American Physiological Society

ARTICLES

Hormone 1 alpha,25-dihydroxyvitamin D3 modulates heat shock response in monocytes

B. S. Polla, A. M. Healy, W. C. Wojno and S. M. Krane

Monocytes, which play a central role in inflammatory reactions, are exposed to elevated temperatures in febrile states or to potential cellular toxins (e.g., reactive oxygen species, immune mediators). We analyzed the heat shock (HS) response in human peripheral blood monocytes and the monocytic line U937 compared with that in dermal fibroblasts. After HS, U937 cells and fibroblasts synthesized mainly the 70- and 83-kDa HS proteins (HSPs), whereas the spectrum of HSPs synthesized by monocytes varied over the range 41-45 degrees C. Incubation with hydrogen peroxide induced synthesis of the 70-kDa HSP in monocytes only. The hormone 1 alpha,25-dihydroxyvitamin D3 [1,25-(OH)2D3] that protects monocytes from thermal injury had similar effects on the HS response in U937 cells, increasing synthesis of HSPs and levels of HSP 70 mRNA and partially preventing the decrease in normal protein synthesis, whereas interferon-gamma had no effect. 1,25-(OH)2D3 did not modify the HS response in fibroblasts, although these cells contained cellular receptors for 1,25-(OH)2D3. 1,25-(OH)2D3 could play a specific role in modulating the HS response in monocytes and related cells.


This article has been cited by other articles:


Home page
 CirculationHome page
J. Nishizawa, A. Nakai, K. Matsuda, M. Komeda, T. Ban, and K. Nagata
Reactive Oxygen Species Play an Important Role in the Activation of Heat Shock Factor 1 in Ischemic-Reperfused Heart
Circulation, February 23, 1999; 99(7): 934 - 941.
[Abstract] [Full Text] [PDF]

Home page
 FASEB J.Home page
J. G. Kiang, I. D. Gist, and G. C. Tsokos
Cytoprotection and regulation of heat shock proteins induced by heat shock in human breast cancer T47-D cells: role of [Ca2+]i and protein kinases
FASEB J, November 1, 1998; 12(14): 1571 - 1579.
[Abstract] [Full Text]

Home page
 J. Appl. Physiol.Home page
W. Y. Su and T. Gordon
In vivo exposure to ozone produces an increase in a 72-kDa heat shock protein in guinea pigs
J Appl Physiol, September 1, 1997; 83(3): 707 - 711.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online