Am J Physiol Cell Physiol Watch the video to see how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Cell Physiol 252: C483-C489, 1987;
0363-6143/87 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow A corrigendum has been published
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Trosper, T. L.
Right arrow Articles by Philipson, K. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Trosper, T. L.
Right arrow Articles by Philipson, K. D.

AJP - Cell Physiology, Vol 252, Issue 5 C483-C489, Copyright © 1987 by American Physiological Society

ARTICLES

Lactate transport by cardiac sarcolemmal vesicles

T. L. Trosper and K. D. Philipson

L-lactate is taken up by cardiac sarcolemmal vesicles in a process that is saturable with respect to L-lactate, stereospecific, associated specifically with the sarcolemmal membrane, and inhibited by other monocarboxylic acids and by the protein modifiers p-chloromercuriphenyl-sulfonate and N-ethylmaleimide. 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid, an inhibitor of the inorganic anion transporter, is without effect. The L-lactate transport is very sensitive to pH. Uptake is stimulated by a proton gradient directed inward and decreased when internal pH is lower than external pH. Passive diffusion of nonionized lactic acid into the vesicles is negligible at physiological pH and appears to remain minor even when external pH is lowered by more than one unit. Also, the mechanism does not require specific Na+-L-lactate contransport. The properties of the L-lactate transporting system in cardiac sarcolemmal vesicles appear similar to those of the monocarboxylate transporter in erythrocytes, hepatocytes, and Ehrlich ascites cells. The present results do not allow a distinction to be made between stepwise interaction of lactate- and H+ or association of nonionized lactic acid with the carrier.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
C. Bollensdorff, A. Knopp, C. Biskup, T. Zimmer, and K. Benndorf
Na+ current through KATP channels: consequences for Na+ and K+ fluxes during early myocardial ischemia
Am J Physiol Heart Circ Physiol, January 1, 2004; 286(1): H283 - H295.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
R. K. Evans, D. D. Schwartz, and L. B. Gladden
Effect of myocardial volume overload and heart failure on lactate transport into isolated cardiac myocytes
J Appl Physiol, March 1, 2003; 94(3): 1169 - 1176.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
M. Inuyama, F. Ushigome, A. Emoto, N. Koyabu, S. Satoh, K. Tsukimori, H. Nakano, H. Ohtani, and Y. Sawada
Characteristics of L-lactic acid transport in basal membrane vesicles of human placental syncytiotrophoblast
Am J Physiol Cell Physiol, September 1, 2002; 283(3): C822 - C830.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
V. V. Kupriyanov, B. Xiang, B. Kuzio, and R. Deslauriers
pH regulation of K+ efflux from myocytes in isolated rat hearts: 87Rb, 7Li, and 31P NMR studies
Am J Physiol Heart Circ Physiol, July 1, 1999; 277(1): H279 - H289.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
S. K. Baker, K. J. A. McCullagh, and A. Bonen
Training intensity-dependent and tissue-specific increases in lactate uptake and MCT-1 in heart and muscle
J Appl Physiol, March 1, 1998; 84(3): 987 - 994.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online