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Am J Physiol Cell Physiol 249: C393-C397, 1985;
0363-6143/85 $5.00
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AJP - Cell Physiology, Vol 249, Issue 5 393-C397, Copyright © 1985 by American Physiological Society

ARTICLES

Selective induction of manganous superoxide dismutase in human monocytes

K. Asayama, R. L. Janco and I. M. Burr

Radioimmunoassays for both human copper-zinc and manganous superoxide dismutases (Cu-Zn SOD and Mn SOD, respectively) have been developed, validated, and utilized to measure the concentrations of these enzymes in cultured monocytes. Monocyte Mn SOD increased 4.7-fold over basal during 3 days of culture, an increase that was markedly enhanced by stimulation with bacterial lipopolysaccharide (LPS). Cu-Zn SOD showed a transient decrease over the culture period but was unaffected by LPS. Stimulation with muramyl dipeptide had minimal effect on Mn SOD and no effect on Cu-Zn SOD during culture, even at a concentration capable of activating the monocytes, as defined by zymosan-induced superoxide production.


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