Am J Physiol Cell Physiol Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Cell Physiol 245: C334-C342, 1983;
0363-6143/83 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brown, D.
Right arrow Articles by DeSousa, R. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brown, D.
Right arrow Articles by DeSousa, R. C.

AJP - Cell Physiology, Vol 245, Issue 5 334-C342, Copyright © 1983 by American Physiological Society

ARTICLES

Correlation between water flow and intramembrane particle aggregates in toad epidermis

D. Brown, A. Grosso and R. C. DeSousa

In abdominal skins of toads (Bufo marinus) challenged with either vasopressin or isoproterenol, the stimulation of transepithelial water flow was accompanied by the appearance of intramembrane particle (IMP) aggregates. These aggregates were found only in the apical plasma membrane of granular cells of the first-reacting cell layer. The effect of vasopressin varied in magnitude and could be selectively blocked by preincubation of the skins with methohexital. This barbiturate also prevented the appearance of IMP aggregates. Preexposure with propranolol had a similar effect in skins challenged with isoproterenol. Linear regression analysis of net water flow vs. the percentage surface occupied by IMP aggregates showed a significant (P less than 0.001) correlation, which applied to data obtained in six different experimental conditions, i.e., vasopressin or isoproterenol alone and either of these agents in combination with methohexital or propranolol. The results reported here in a nonurinary epithelium (toad epidermis) suggest that the appearance of IMP aggregates is a general response in epithelia undergoing adenosine 3',5'-cyclic monophosphate-mediated changes in water permeability.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
C. Silberstein, R. Bouley, Y. Huang, P. Fang, N. Pastor-Soler, D. Brown, and A. N. Van Hoek
Membrane organization and function of M1 and M23 isoforms of aquaporin-4 in epithelial cells
Am J Physiol Renal Physiol, September 1, 2004; 287(3): F501 - F511.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
T.-X. Sun, A. Van Hoek, Y. Huang, R. Bouley, M. McLaughlin, and D. Brown
Aquaporin-2 localization in clathrin-coated pits: inhibition of endocytosis by dominant-negative dynamin
Am J Physiol Renal Physiol, June 1, 2002; 282(6): F998 - F1011.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online