Am J Physiol Cell Physiol Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Cell Physiol 244: C348-C355, 1983;
0363-6143/83 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lawrence, J. C.
Right arrow Articles by Salsgiver, W. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lawrence, J. C., Jr
Right arrow Articles by Salsgiver, W. J.

AJP - Cell Physiology, Vol 244, Issue 5 348-C355, Copyright © 1983 by American Physiological Society

ARTICLES

Levels of enzymes of energy metabolism are controlled by activity of cultured rat myotubes

J. C. Lawrence Jr and W. J. Salsgiver

We have investigated the effects of inhibiting the spontaneous activity of cultured rat myotubes on several representative enzymes of glycolytic and oxidative metabolism. The results presented demonstrate that contractile activity in the absence of nerves can regulate the amounts of these enzymes and indicate that muscle activity may partially control development of the metabolic types of muscle fibers. Control muscle cells have relatively high levels of glycolytic enzymes and low oxidative enzymes and metabolically most closely resemble fast glycolytic fibers. The divalent cation ionophore A23187 caused enzyme levels of the cultured cells to change towards those found in tonically contracting skeletal muscle fibers in vivo. The evidence presented suggests that calcium may mediate certain of the effects associated with muscle contraction on enzymes of energy metabolism.


This article has been cited by other articles:


Home page
 FASEB J.Home page
E. O. OJUKA, T. E. JONES, D.-H. HAN, M. CHEN, and J. O. HOLLOSZY
Raising Ca2+ in L6 myotubes mimics effects of exercise on mitochondrial biogenesis in muscle
FASEB J, April 1, 2003; 17(6): 675 - 681.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
E. O. Ojuka, T. E. Jones, D.-H. Han, M. Chen, B. R. Wamhoff, M. Sturek, and J. O. Holloszy
Intermittent increases in cytosolic Ca2+ stimulate mitochondrial biogenesis in muscle cells
Am J Physiol Endocrinol Metab, November 1, 2002; 283(5): E1040 - E1045.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
D. Freyssenet, M. Di Carlo, and D. A. Hood
Calcium-dependent Regulation of Cytochrome c Gene Expression in Skeletal Muscle Cells. IDENTIFICATION OF A PROTEIN KINASE C-DEPENDENT PATHWAY
J. Biol. Chem., April 2, 1999; 274(14): 9305 - 9311.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
E. O. Ojuka, T. E. Jones, L. A. Nolte, M. Chen, B. R. Wamhoff, M. Sturek, and J. O. Holloszy
Regulation of GLUT4 biogenesis in muscle: evidence for involvement of AMPK and Ca2+
Am J Physiol Endocrinol Metab, May 1, 2002; 282(5): E1008 - E1013.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online